HBEGF Protein (AA 63-148)
Kurzübersicht für HBEGF Protein (AA 63-148) (ABIN2018329)
Target
Alle HBEGF Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 63-148
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Produktmerkmale
- ED50 <0.5 ng/mL, measured in a cell proliferation assay using 3T3 cells.
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Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
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Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 20-160) protein (Fc Tag)
HBEGF Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 24-160) protein (Fc Tag)HBEGF Spezies: Maus Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 24-160) protein (His tag)HBEGF Spezies: Maus Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 63-148) protein (His-IF2DI Tag)HBEGF Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Lagerung
- -80 °C
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Informationen zur Lagerung
- Lyophilized recombinant Human HB-EGF remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human HB-EGF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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Haltbarkeit
- 6 months
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- HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
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Andere Bezeichnung
- Proheparin-Binding EGF-Like Growth Factor (HB-EGF)
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Hintergrund
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Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds the EGF receptor with higher affinity and is thus more mitogenic, probably due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin.
Synonyms: DTR, DTS, HEGFL -
Molekulargewicht
- 12-14 kDa, observed by reducing SDS-PAGE.
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UniProt
- Q99075
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Pathways
- RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Target
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