NOG Protein (AA 20-232)

Produktnummer ABIN2018288

Dieses Recombinant NOG-Protein wird in CHO Cells produziert. Es ist 1 Publikation verfügbar.

Kurzübersicht für NOG Protein (AA 20-232) (ABIN2018288)

Target: NOG (Noggin (NOG))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: CHO Cells

Reinheit: > 95 % as analyzed by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 20-232

Produktmerkmale: ED50< 60 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant murine Nogginremains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Nogginshould be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Referenzen

Bohnenpoll, Wittern, Mamo, Weiss, Rudat, Kleppa, Schuster-Gossler, Wojahn, Lüdtke, Trowe, Kispert: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).

Antigendetails

Target: NOG (Noggin (NOG))

Andere Bezeichnung: Noggin

Hintergrund: Noggin, also known as NOG, is a homodimeric glycoprotein that binds to and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors.Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients that regulate cellular responses in a concentration-dependent manner.
Synonyms: NOG

Molekulargewicht: 29-31 kDa, observed by reducing SDS-PAGE.

UniProt: P97466

Pathways: Stem Cell Maintenance, Tube Formation