IL-5 Protein (AA 20-134)

Produktnummer ABIN2018124

Dieses Recombinant IL-5-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für IL-5 Protein (AA 20-134) (ABIN2018124)

Target: IL-5 (IL5) (Interleukin 5 (IL5))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 20-134

Produktmerkmale: ED50 < 1.0 ng/mL, measured by a cell proliferation assay using TF-1 Cells, corresponding to a specific activity of > 1.0x 10^6 units/mg.
AA 20-134, expressed with an N-terminal Met.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against 25 mM Tris, pH 8.0.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Human Interleukin-5 (rhIL-5) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-5 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: IL-5 (IL5) (Interleukin 5 (IL5))

Andere Bezeichnung: Interleukin-5 (IL-5)

Hintergrund: Interleukin-5 (IL-5), produced by mast cells, T cells and eosinophils, is responsible for the activities attributed to eosinophil differentiating factor, B cell growth factor II and T cell-replacing factor (TRF). It can increase production and mobilization of eosinophils and CD34+ progenitors from the bone marrow. IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release.Recombinant Human Interleukin-5 (rhIL-5) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 116 amino acids each. A fully biologically active molecule, rhIL-5 has a molecular mass of 26.5 kDa analyzed by non-reducing SDS-PAGE.
Synonyms: EDF, BCDFII, TRF

Molekulargewicht: 26.5 kDa, observed by non-reducing SDS-PAGE.

UniProt: P05113

Pathways: JAK-STAT Signalweg, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Feeding Behaviour