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IL-21 Protein (AA 25-155)

Recombinant IL-21-Protein exprimiert in Escherichia coli (E. coli).
Produktnummer ABIN2018094

Kurzübersicht für IL-21 Protein (AA 25-155) (ABIN2018094)

Target

Alle IL-21 (IL21) Proteine anzeigen
IL-21 (IL21) (Interleukin 21 (IL21))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 40
  • 18
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 38
  • 16
  • 6
  • 4
  • 1
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % by SDS-PAGE analysis.
  • Proteineigenschaft

    AA 25-155

    Produktmerkmale

    ED50 < 0.5 ng/mL, measured by a cell growth inhibition assay using Mino cells, corresponding to a specific activity of > 2.0x 10^6 units/mg.
    AA 25-155, expressed with an N-terminal Met.

    Endotoxin-Niveau

    < 0.2 EU/μg, determined by LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstituted in ddH2O at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Lyophilized recombinant human Interleukin-21 (rhIL-21) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-21 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

    Haltbarkeit

    6 months
  • Target

    IL-21 (IL21) (Interleukin 21 (IL21))

    Andere Bezeichnung

    Interleukin-21(IL-21)

    Hintergrund

    Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor gamma chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells, and the IL-21 receptor is highly expressed on CD4+ and CD8+ B cells, indeed, IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21 up-regulates and down-regulates the production of IgG1 and IgE by B cells, respectively, and diminishes the severity of allergy and asthma. In some case, IL-21 also induces the apoptosis of B cells. The other roles of IL-21 include regulation of innate immune systems, implication on autoimmunity, and antitumor actions.Recombinant human Interleukin-21 (rhIL-21) produced in E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.4 kDa analyzed by reducing SDS-PAGE.
    Synonyms: Za11

    Molekulargewicht

    15.4 kDa, observed by reducing SDS-PAGE.

    UniProt

    Q9HBE4

    Pathways

    JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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