IL18BP Protein (AA 31-194)

Produktnummer ABIN2018075

Dieses Recombinant IL18BP-Protein wird in CHO Cells exprimiert.

Kurzübersicht für IL18BP Protein (AA 31-194) (ABIN2018075)

Target: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: CHO Cells

Reinheit: > 95 % as analyzed by SDS-PAGE and HPLC.

Produktdetails

Proteineigenschaft: AA 31-194

Produktmerkmale: ED50 < 30 ng /mL, measured in a bioassay using KG-1 cells in the presence of 50 ng/mL Human IL-18.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Human IL-18BP remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human IL-18BP should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Andere Bezeichnung: Interleukin-18 Binding Protein (IL-18 BP)

Hintergrund: Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
Synonyms: Tadekinig-alfa, IL18BP

Molekulargewicht: 42-44 kDa, observed by reducing SDS-PAGE.

UniProt: O95998