IL-13 Protein (AA 19-132)

Produktnummer ABIN2018016

Produktdetails

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 19-132

Spezies: Human

Quelle: CHO Cells

Produktmerkmale: ED50 < 15 ng/mL, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 6.7x10^5 units/mg.

Reinheit: > 95 % as analyzed by SDS-PAGE.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human Interleukin 13 (IL-13) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-13 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Andere Bezeichnung: Interleukin 13 (IL-13) (IL13 Produkte)

Hintergrund: Interleukin 13 (IL-13) is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and mouse IL-13 is cross-species reactive.Recombinant human interleukin 13 expressed in CHO cells is glycosylated protein with molecular weight range from 25 to 45 kDa shown in non-reducing SDS-PAGE.
Synonyms: NC30 (Human), P600 (Murine),IL-13 (human)

Molekulargewicht: 25-45 kDa, observed by non-reducing SDS-PAGE.

UniProt: P35225

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport