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Interferon gamma Protein (IFNG) (AA 23-155)

Dieses Recombinant Interferon gamma-Protein wird in Escherichia coli (E. coli) produziert.
Produktnummer ABIN2018007

Kurzübersicht für Interferon gamma Protein (IFNG) (AA 23-155) (ABIN2018007)

Target

Alle Interferon gamma (IFNG) Proteine anzeigen
Interferon gamma (IFNG)

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 26
  • 14
  • 14
  • 4
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  • 2
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  • 1
  • 1
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Maus

Quelle

  • 57
  • 34
  • 11
  • 5
  • 2
  • 2
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as analyzed by reducing SDS-PAGE.
  • Proteineigenschaft

    AA 23-155

    Produktmerkmale

    ED50<0.15 ng/mL, measured by cytotoxicity assay using WEHI-279 cells.
    AA 23-155, expressed with an N-terminal Met.

    Endotoxin-Niveau

    < 1 EU/μg, determined by LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstituted in ddH2O or PBS at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Lyophilized recombinant mouse IFN gamma (rmIFN-γ) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmIFN-γ should be stable up to 1week at 4°C or up to 2 months at -20°C.

    Haltbarkeit

    6 months
  • Target

    Interferon gamma (IFNG)

    Andere Bezeichnung

    Interferon-gamma (IFN-Gamma)

    Hintergrund

    Sharing 41 % sequence identity with human Interferon gamma (hIFN--γ), mouse IFN gamma (mIFN--γ) is a macrophage-activating factor.The active form of IFN--γ is an antiparallel dimer that sets off IFN--γ/JAK/STAT pathway. IFN--γ signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity.While IFN--γ-induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN--γ is also implicated in resistance to NK cell and CTL responses and in immune escape in avariety of cancers. Recombinant mouse IFN gamma (rmIFN-γ) produced in E. coli is a non-glycosylated polypeptide chain of 134 amino acids. A fully biologically active molecule, rmIFN--γ has a molecular mass of 15 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
    Synonyms: Type II interferon, T cell interferon, MAF, IFNG, IFG, IFI

    Molekulargewicht

    15 kDa, observed by reducing SDS-PAGE.

    UniProt

    P01580

    Pathways

    Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie
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