Interferon gamma Protein (IFNG) (AA 23-155)
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- Target Alle Interferon gamma (IFNG) Proteine anzeigen
- Interferon gamma (IFNG)
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 23-155
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Spezies
- Maus
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Quelle
- Escherichia coli (E. coli)
- Produktmerkmale
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ED50<0.15 ng/mL, measured by cytotoxicity assay using WEHI-279 cells.
AA 23-155, expressed with an N-terminal Met. - Reinheit
- > 95 % as analyzed by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1 EU/μg, determined by LAL method.
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Lyophilized recombinant mouse IFN gamma (rmIFN-γ) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmIFN-γ should be stable up to 1week at 4°C or up to 2 months at -20°C.
- Haltbarkeit
- 6 months
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- Target
- Interferon gamma (IFNG)
- Andere Bezeichnung
- Interferon-gamma (IFN-Gamma) (IFNG Produkte)
- Hintergrund
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Sharing 41 % sequence identity with human Interferon gamma (hIFN--γ), mouse IFN gamma (mIFN--γ) is a macrophage-activating factor.The active form of IFN--γ is an antiparallel dimer that sets off IFN--γ/JAK/STAT pathway. IFN--γ signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity.While IFN--γ-induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN--γ is also implicated in resistance to NK cell and CTL responses and in immune escape in avariety of cancers. Recombinant mouse IFN gamma (rmIFN-γ) produced in E. coli is a non-glycosylated polypeptide chain of 134 amino acids. A fully biologically active molecule, rmIFN--γ has a molecular mass of 15 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
Synonyms: Type II interferon, T cell interferon, MAF, IFNG, IFG, IFI - Molekulargewicht
- 15 kDa, observed by reducing SDS-PAGE.
- UniProt
- P01580
- Pathways
- Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie
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