FGF2 Protein (AA 10-155)

Produktnummer ABIN2017858

Produktdetails

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 10-155

Spezies: Rind (Kuh)

Quelle: Escherichia coli (E. coli)

Produktmerkmale: ED50 < 1.0 ng/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 1 x 10^6 units/mg.

Reinheit: > 95 % by SDS-PAGE analysis.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant bovine Fibroblast Growth Factor-basic (rbFGF-basic) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rbFGF-basic remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Andere Bezeichnung: Fibroblast Growth Factor-Basic (FGF-Basic) (FGF2 Produkte)

Hintergrund: Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the beta trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including cardiomycotes, fibroblasts, and vascular cells. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling. The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury.Recombinant bovine Fibroblast Growth Factor-basic (rbFGF-basic) produced in E. coli is a single non-glycosylated polypeptide chain containing 146 amino acids. A fully biologically active molecule, rbFGF-basic has a molecular mass of 16.4 kDa analyzed by reducing SDS-PAGE.
Synonyms: FGF-2, BFGF, FGFB, HBGF-2

Molekulargewicht: 16.4 kDa, observed by reducing SDS-PAGE.

UniProt: P03969

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteine