FGF8 Protein (AA 23-215)
Kurzübersicht für FGF8 Protein (AA 23-215) (ABIN2017830)
Target
Alle FGF8 Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 23-215
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Produktmerkmale
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ED50 < 5.0 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence of 1 μg/mL of heparin, corresponding to a specific activity of > 2.0x 10^5 units/mg.
AA 23-215, expressed with an N-terminal Met. -
Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstituted in ddH2O at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Lagerung
- -80 °C
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Informationen zur Lagerung
- Lyophilized recombinant human Fibroblast Growth Factor-8 (rhFGF-8) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhFGF-8 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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Haltbarkeit
- 6 months
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- FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))
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Andere Bezeichnung
- Fibroblast Growth Factor-8 (FGF-8)
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Hintergrund
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Fibroblast Growth Factor-8 (FGF-8) is a heparin-binding growth factor of the FGF family. There are 4 known forms of FGF8 produced by alternative splicing: FGF8a, FGF-8b, FGF-8e and FGF-8f. The human and mouse FGF8b are identical of aa sequences. FGF-8 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF-8 is required for normal brain, eye, ear and limb development during embryogenesis. It is also required for normal development of the gonadotropin- releasing hormone (GnRH) neuronal system.Recombinant human Fibroblast Growth Factor-8 (rhFGF-8) produced in E. coli is a single non-glycosylated polypeptide chain containing 194 amino acids. A fully biologically active molecule, rhFGF-8 has a molecular mass of 22.5 kDa analyzed by reducing SDS-PAGE.
Synonyms: FGF-8b, AIGF, HBGF -
Molekulargewicht
- 22.5kDa, observed by reducing SDS-PAGE.
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UniProt
- P55075
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Pathways
- RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis
Target
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