CNTF Protein (AA 2-200)
-
- Target Alle CNTF Proteine anzeigen
- CNTF (Ciliary Neurotrophic Factor (CNTF))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 2-200
-
Spezies
- Human
-
Quelle
- Escherichia coli (E. coli)
- Produktmerkmale
- ED50 < 200 ng/mL, measured cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 5x10^3 units/mg.
- Reinheit
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product CNTF Protein
-
Ciliary Neurotrophic Factor (CNTF) (Active) protein
CNTF Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Ciliary Neurotrophic Factor (CNTF) (AA 1-200) protein (His tag)CNTF Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Ciliary Neurotrophic Factor (CNTF) (AA 1-200) protein (His tag)CNTF Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Ciliary Neurotrophic Factor (CNTF) (AA 1-200) protein (GST tag)CNTF Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Ciliary Neurotrophic Factor (CNTF) (AA 1-198) protein (Strep Tag)Crystallography grade CNTF Spezies: Maus Wirt: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Ciliary Neurotrophic Factor (CNTF) (AA 4-196), (partial) protein (His tag)CNTF Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % ELISA
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Lyophilized recombinant human Ciliary Neurotrophic Factor (rhCNTF) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhCNTF remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Haltbarkeit
- 6 months
-
- Target
- CNTF (Ciliary Neurotrophic Factor (CNTF))
- Abstract
- CNTF Produkte
- Synonyme
- GPA Protein, CNTF Protein, HCNTF Protein, AI429687 Protein, ciliary neurotrophic factor Protein, CNTF Protein, Cntf Protein
- Hintergrund
-
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor beta subunit, and a CNTF specific alpha receptor subunit. Upon binding to the CNTF, the beta subunit of the CNTF receptor will undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons.Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: Ciliary Neurotrophic Factor - Molekulargewicht
- 22.8 kDa, observed by reducing SDS-PAGE.
- UniProt
- P26441
- Pathways
- JAK-STAT Signalweg
-
