Complement C4 Protein

Produktnummer ABIN1880330

Dieses Native Complement C4-Protein wird in Human produziert.

Kurzübersicht für Complement C4 Protein (ABIN1880330)

Target: Complement C4 (C4) (Complement 4 (C4))

Protein-Typ: Native

Spezies: Human

Quelle: Human

Reinheit: > 90 % by SDS-PAGE

Produktdetails

Aufreinigung: Purified

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10mM PBS (pH 7.4).

Lagerung: 4 °C

Antigendetails

Target: Complement C4 (C4) (Complement 4 (C4))

Andere Bezeichnung: Complement C4

Hintergrund: Complement C4 encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [

Pathways: Komplementsystem