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Calreticulin 3 Protein (CALR3) (AA 20-384)

Recombinant Calreticulin 3-Protein exprimiert in Escherichia coli (E. coli).
Produktnummer ABIN1692465

Kurzübersicht für Calreticulin 3 Protein (CALR3) (AA 20-384) (ABIN1692465)

Target

Alle Calreticulin 3 (CALR3) Proteine anzeigen
Calreticulin 3 (CALR3)

Protein-Typ

Recombinant

Spezies

  • 4
  • 2
  • 1
Human

Quelle

  • 3
  • 2
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as determined by reducing SDS-PAGE.
  • Proteineigenschaft

    AA 20-384

    Verwendungszweck

    Recombinant Human Calreticulin-3/CALR3/CRT2

    Sequenz

    MTVYFQEEFL DGEHWRNRWL QSTNDSRFGH FRLSSGKFYG HKEKDKGLQT TQNGRFYAIS ARFKPFSNKG KTLVIQYTVK HEQKMDCGGG YIKVFPADID QKNLNGKSQY YIMFGPDICG FDIKKVHVIL HFKNKYHENK KLIRCKVDGF THLYTLILRP DLSYDVKIDG QSIESGSIEY DWNLTSLKKE TSPAESKDWE QTKDNKAQDW EKHFLDASTS KQSDWNGDLD GDWPAPMLQK PPYQDGLKPE GIHKDVWLHR KMKNTDYLTQ YDLSEFENIG AIGLELWQVR SGTIFDNFLI TDDEEYADNF GKATWGETKG PEREMDAIQA KEEMKKAREE EEEELLSGKI NRHEHYFNQF HRRNEL

    Produktmerkmale

    Recombinant Human calreticulin-3/CALR3/CRT2 is produced with our E. coli expression system. The target protein is expressed with sequence (Thr20-Leu384) of Human CALR3 fused with a 6His tag at the C-terminus.

    Sterilität

    0.2 μm filtered

    Endotoxin-Niveau

    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

    Handhabung

    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

    Lagerung

    4 °C/-20 °C/-80 °C

    Informationen zur Lagerung

    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.

    Haltbarkeit

    5 months
  • Target

    Calreticulin 3 (CALR3)

    Andere Bezeichnung

    CALR3

    Sub Type

    Fusionprotein

    Hintergrund

    Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain.
    Alternative Names: Calreticulin-3, calreticulin-2, calsperin, CALR3, CRT2

    Molekulargewicht

    42.9 kDa

    UniProt

    Q96L12

    Pathways

    Activation of Innate immune Response
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