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BLK Protein (B Lymphoid Tyrosine Kinase) (AA 2-505) (His tag)

BLK Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1692105
$385.00
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
Lieferung in 4 Werktagen
  • Target Alle BLK Proteine anzeigen
    BLK (B Lymphoid Tyrosine Kinase (BLK))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 2-505
    Spezies
    • 9
    • 1
    Human
    Quelle
    • 5
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses BLK Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human Tyrosine-Protein Kinase Blk/BLK (C-6His)
    Sequenz
    GLVSSKKPDK EKPIKEKDKG QWSPLKVSAQ DKDAPPLPPL VVFNHLTPPP PDEHLDEDKH FVVALYDYTA MNDRDLQMLK GEKLQVLKGT GDWWLARSLV TGREGYVPSN FVARVESLEM ERWFFRSQGR KEAERQLLAP INKAGSFLIR ESETNKGAFS LSVKDVTTQG ELIKHYKIRC LDEGGYYISP RITFPSLQAL VQHYSKKGDG LCQRLTLPCV RPAPQNPWAQ DEWEIPRQSL RLVRKLGSGQ FGEVWMGYYK NNMKVAIKTL KEGTMSPEAF LGEANVMKAL QHERLVRLYA VVTKEPIYIV TEYMARGCLL DFLKTDEGSR LSLPRLIDMS AQIAEGMAYI ERMNSIHRDL RAANILVSEA LCCKIADFGL ARIIDSEYTA QEGAKFPIKW TAPEAIHFGV FTIKADVWSF GVLLMEVVTY GRVPYPGMSN PEVIRNLERG YRMPRPDTCP PELYRGVIAE CWRSRPEERP TFEFLQSVLE DFYTATERQY ELQPLEHHHH HH
    Produktmerkmale
    Recombinant Human Tyrosine-Protein Kinase Blk/BLK is produced with our E. coli expression system. The target protein is expressed with sequence (Gly2-Pro505) of Human BLK fused with a 6His tag at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH 7.4.
    Vorsichtsmaßnahmen
    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    BLK (B Lymphoid Tyrosine Kinase (BLK))
    Andere Bezeichnung
    Tyrosine-Protein Kinase Blk/BLK (BLK Produkte)
    Synonyme
    bltk, si:dkey-33i22.2, zgc:136231, MODY11, BLK proto-oncogene, Src family tyrosine kinase, B lymphoid kinase, blk, BLK, Blk
    Sub Type
    Fusionprotein
    Hintergrund
    Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
    Alternative Names: Tyrosine-Protein Kinase Blk, B Lymphocyte Kinase, p55-Blk, BLK
    Molekulargewicht
    58.7 kDa
    UniProt
    P51451
    Pathways
    Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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