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VEGF 165 (Homodimer) (Active) Protein

This anti- antibody (ABIN1589667) is a Insect Cells antibody detecting in . Suitable for Human.
Produktnummer ABIN1589667

Kurzübersicht für VEGF 165 (Homodimer) (Active) Protein (ABIN1589667)

Target

VEGF 165

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 19
  • 2
  • 1
Human

Quelle

  • 10
  • 7
  • 1
  • 1
  • 1
  • 1
  • 1
Insektenzellen

Reinheit

> 95 % by SDS-PAGE
  • Proteineigenschaft

    Homodimer

    Verwendungszweck

    VEGF165

    Sequenz

    APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

    Spezifität

    Chromosomal location:6p12

    Produktmerkmale

    Length (aa):165
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  • Applikationshinweise

    The ED50 for stimulation of cell proliferation by human umbilical vein endothelial cells for VEGF165 has been determined to be in the range of 1-4 ng/mL.

    Kommentare

    Cytokines & Growth Factors

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    The lyophilized VEGF165 should be reconstituted in 50 mM acetic acid to a concentration not lower than 50 μg/mL. For long term storage we recommend to add at least 0.1 % human or bovine serum albumin.

    Buffer

    50 mM acetic acid

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted VEGF165 should be stored in working aliquots at -20°C.

    Haltbarkeit

    6 months
  • Caolo, Swennen, Chalaris, Wagenaar, Verbruggen, Rose-John, Molin, Vooijs, Post: "ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis." in: Angiogenesis, Vol. 18, Issue 1, pp. 13-22, (2014) (PubMed).

  • Target

    VEGF 165

    Andere Bezeichnung

    VEGF165

    Hintergrund

    Human Vascular Endothelial Growth Factor VEGF165, a 23 kDa protein consisting of 165 amino acid residues, is produced as a homodimer. VEGF is a polypeptide growth factor and a member of the platelet-derived growth factor family. It is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. Two high-affinity tyrosine kinase receptors for VEGF165 have been identified, VEGFR-1 (FLT-1), and VEGFR-2 (KDR). Consistent with the endothelial cell-specific action of VEGF165, expression of both receptor genes has been found predominantly but not exclusively on endothelial cells. Expression of VEGFR-1 was also found on human monocytes, neutrophils (PMNs), bovine brain pericytes and villous and extra villous trophoblast. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo. VEGF165 is also a chemo attractant molecule for monocytes and endothelial cells. 5 different proteins are generated by differential splicing: VEGF121, VEGF145, VEGF165, VEGF189 and VEGF206. The most abundant form is VEGF165. Whereas VEGF121 and VEGF165 are secreted proteins, VEGF145, VEGF189 and VEGF206 are strongly cell-associated. The isoforms VEGF145, VEGF165 and VEGF189 bind to heparin with high affinity. VEGF165 is apparently a homo-dimer, but preparations of VEGF165 show some heterogeneity on SDS gels, depending on the secretion of different glycosylation patterns. All dimeric forms have similar biological activities but their bioavailability is very different. There is good evidence that different cells and tissues express different VEGF isoforms. The other members of this increasing growth factor family are VEGF-B, -C, -D and -E. Another member is the Placenta growth factor PlGF
    Synonyms: vascular endothelial growth factor A, VEGFA, VPF, VEGF, MVCD1

    Molekulargewicht

    45.0 kDa

    Gen-ID

    7422

    NCBI Accession

    NM_001025366, NP_001020537

    UniProt

    P15692
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