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GM-CSF Protein

Dieses Recombinant GM-CSF-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN1589646

Kurzübersicht für GM-CSF Protein (ABIN1589646)

Target

Alle GM-CSF (CSF2) Proteine anzeigen
GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 31
  • 14
  • 12
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 35
  • 9
  • 8
  • 5
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 98 % by SDS-PAGE
  • Verwendungszweck

    GM-CSF

    Sequenz

    APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQE

    Spezifität

    Chromosomal location:5q31.1

    Produktmerkmale

    Length (aa):127

    Endotoxin-Niveau

    < 0.1 ng per μg of GM-CSF
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  • Applikationshinweise

    The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <0.1 ng/mL corresponding to a specific activity of ≥1 x 10^7 units/mg.

    Kommentare

    Cytokines & Growth Factors

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    The lyophilized rh GM-CSF is soluble in water and most aqueous buffers and can be reconstituted in water to a concentration of 0.1 mg/mL. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.

    Buffer

    PBS, pH 7.2

    Lagerung

    RT,-20 °C

    Informationen zur Lagerung

    The lyophilized powder although stable at room temperature for 3 weeks, is best stored desiccated at -20°C. Reconstituted GM-CSF should be stored in working aliquots at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Target

    GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

    Andere Bezeichnung

    GM-CSF

    Hintergrund

    Recombinant human Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), a 14,5 kDa protein consisting of 127 amino acid residues (Ala18-Glu144), is a potent species specific stimulator of bone marrow cells and several other cell types. GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages and eosinophils. GM-CSF has also been reported to have a functional role on non-hematopoietic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. GM-CSF is species specific and human GM-CSF has no biological effects on mouse cells. GM-CSF exerts its biological effects through binding to specific cell surface receptors. The high affinity receptors required for human GM-CSF signal transduction have been shown to be heterodimers consisting of a GM-CSF-specific α chain and a common β chain that is shared by the high-affinity receptors for IL-3 and IL-5.
    Synonyms: CSF2, GM-CSF

    Molekulargewicht

    14.5 kDa

    Gen-ID

    1437

    NCBI Accession

    NM_000758, NP_000749

    Pathways

    JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin
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