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IL-4 Protein

This anti-IL-4 antibody (ABIN1589638) is a Escherichia coli (E. coli) antibody detecting IL-4 in . Suitable for Human.
Produktnummer ABIN1589638

Kurzübersicht für IL-4 Protein (ABIN1589638)

Target

Alle IL-4 (IL4) Proteine anzeigen
IL-4 (IL4) (Interleukin 4 (IL4))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 39
  • 27
  • 9
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 55
  • 20
  • 17
  • 12
  • 5
  • 4
  • 2
Escherichia coli (E. coli)

Reinheit

> 98 % by SDS-PAGE
  • Verwendungszweck

    IL-4

    Sequenz

    MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

    Spezifität

    Chromosomal location:5q31.1

    Produktmerkmale

    Length (aa):130

    Endotoxin-Niveau

    < 0.1 ng per μg of IL-4
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  • Applikationshinweise

    The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is 0.1-0.5 ng/mL.

    Kommentare

    Cytokines & Growth Factors

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    The lyophilized IL-4 should be reconstituted in water to a concentration not less than 100 μg/mL. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.

    Buffer

    PBS

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    RT,0 °C,4 °C,-20 °C

    Informationen zur Lagerung

    The lyophilized IL-4, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted IL-4 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
  • Target

    IL-4 (IL4) (Interleukin 4 (IL4))

    Andere Bezeichnung

    IL-4

    Hintergrund

    IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 130 amino acid residues
    Synonyms: IL4, BSF1, IL-4, BCGF1, BSF-1, BCGF-1

    Molekulargewicht

    14.9 kDa

    Gen-ID

    3565

    NCBI Accession

    NM_000589, NP_000580

    UniProt

    P05112

    Pathways

    JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation
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