IL-4 Protein
Kurzübersicht für IL-4 Protein (ABIN1589638)
Target
Alle IL-4 (IL4) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Verwendungszweck
- IL-4
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Sequenz
- MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
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Spezifität
- Chromosomal location:5q31.1
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Produktmerkmale
- Length (aa):130
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Endotoxin-Niveau
- < 0.1 ng per μg of IL-4
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Applikationshinweise
- The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is 0.1-0.5 ng/mL.
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Kommentare
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Cytokines & Growth Factors
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- The lyophilized IL-4 should be reconstituted in water to a concentration not less than 100 μg/mL. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.
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Buffer
- PBS
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- RT,0 °C,4 °C,-20 °C
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Informationen zur Lagerung
- The lyophilized IL-4, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted IL-4 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
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- IL-4 (IL4) (Interleukin 4 (IL4))
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Andere Bezeichnung
- IL-4
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Hintergrund
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IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 130 amino acid residues
Synonyms: IL4, BSF1, IL-4, BCGF1, BSF-1, BCGF-1 -
Molekulargewicht
- 14.9 kDa
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Gen-ID
- 3565
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NCBI Accession
- NM_000589, NP_000580
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UniProt
- P05112
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Pathways
- JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation
Target
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