Calreticulin Protein (CALR) (His tag)

Produktnummer ABIN1344123

Produktdetails

Target: Calreticulin (CALR)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Calreticulin Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Verwendungszweck: Calreticulin (human) (rec.) (His)

Kreuzreaktivität: Human

Produktmerkmale: Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.

Reinheit: >90 % (SDS-PAGE)

Sterilität: Sterile filtered

Endotoxin-Niveau: <1EU/μg purified protein (LAL test).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.

Handhabung: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: Calreticulin (CALR)

Andere Bezeichnung: Calreticulin (CALR Produkte)

Hintergrund:

CRP55, Calregulin, Endoplasmic Reticulum Resident Protein 60, ERp60, grp60

Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the 'calreticulin/calnexin cycle' that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

Molekulargewicht: ~55kDa (SDS-PAGE)

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response