CPSF4 Protein (His tag)
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- Target Alle CPSF4 Proteine anzeigen
- CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses CPSF4 Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Reinheit
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product CPSF4 Protein
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Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 1-269) protein (His tag)
custom-made CPSF4 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 1-244) protein (GST tag)CPSF4 Spezies: Human Wirt: Wheat germ Recombinant ELISA, WB, AA, AP
Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 1-211) protein (His tag)custom-made CPSF4 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Kommentare
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Synonyms: cleavage and polyadenylation specific factor 4, 30kDa, CPSF30, NAR, NEB1
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M UREA, 10% glycerol
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Avoid repeated freezing and thawing cycles.
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- Target
- CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
- Andere Bezeichnung
- CPSF4 (CPSF4 Produkte)
- Hintergrund
- Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of CPSF4 an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Recombinant human CPSF4 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molekulargewicht
- 29.9 kDa (267aa)
- NCBI Accession
- NP_001075028
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