MVK Protein (His tag)

Produktnummer ABIN1098525

Dieses Recombinant MVK-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für MVK Protein (His tag) (ABIN1098525)

Target: MVK (Mevalonate Kinase (MVK))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: > 90 % by SDS - PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses MVK Protein ist gelabelt mit His tag.

Aufreinigung: purified by chromatography

Anwendungsinformationen

Kommentare:

Synonyms: Mevalonate kinase, LRBP, MK, MVLK

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 10% glycerol, 1 MM DTT

Lagerung: 4 °C

Informationen zur Lagerung: Avoid repeated freezing and thawing cycles.

Antigendetails

Target: MVK (Mevalonate Kinase (MVK))

Andere Bezeichnung: MVK

Hintergrund: Mevalonate kinase, also known as MVK, belongs to the GHMP kinase family. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive,hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Recombinant human MVK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 44.8 kDa (419aa) confirmed by MALDI-TOF

NCBI Accession: NP_001107657