Lipocalin 2 Protein (LCN2) (full length)
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- Target Alle Lipocalin 2 (LCN2) Proteine anzeigen
- Lipocalin 2 (LCN2)
- Protein-Typ
- Native
- Proteineigenschaft
- full length
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Spezies
- Human
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Quelle
- Human
- Applikation
- Western Blotting (WB), SDS-PAGE (SDS), ELISA, Latex enhanced turbidimetric Immunoassay (LETIA)
- Aufreinigung
- Purified from human urine
- Reinheit
- > 95 %(SDS-PAGE)
- Top Product
- Discover our top product LCN2 Protein
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Lipocalin 2 (LCN2) (AA 21-198) protein (Fc Tag)
LCN2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-198) protein (His tag)LCN2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-198) protein (His tag)LCN2 Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-200) protein (Fc Tag)LCN2 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) protein (His tag)LCN2 Spezies: Maus Wirt: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Lipocalin 2 (LCN2) (AA 1-198) protein (GST tag)LCN2 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 Spezies: Ratte Wirt: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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- Applikationshinweise
- calibrator ,immunogen and other possible
- Kommentare
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Full length native Neutrophil gelatinase-associated lipocalin protein
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS
- Lagerung
- -20 °C
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- Target
- Lipocalin 2 (LCN2)
- Andere Bezeichnung
- Neutrophil gelatinase-associated lipocalin (LCN2 Produkte)
- Hintergrund
- Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
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