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Depletion of glycolytic intermediates led to a consistent decrease in TXNIP expression in response to 1,25(OH)2D3, an effect that coincided with the activation of AMPK (zeige PRKAA1 ELISA Kits) signaling and a reduction in c-MYC (zeige MYC ELISA Kits) expression.
We found no evidence of decreased TXNIP DNA methylation (zeige HELLS ELISA Kits) or increased gene expression in metabolic target tissues of offspring exposed to maternal diabetes. Further studies are needed to confirm and understand the paradoxical SAT TXNIP DNA methylation (zeige HELLS ELISA Kits) and gene expression changes in O-GDM subjects
the association of TXNIP (thioredoxin-interacting protein) with NLRP3 (zeige NLRP3 ELISA Kits) induced by ROS (zeige ROS1 ELISA Kits) promoted NLRP3 (zeige NLRP3 ELISA Kits) inflammasome activation in senescent HUVEC endothelial cells
histone acetylation serves as a key regulator of glucose-induced increase in TXNIP gene expression
thioredoxin-interacting protein deficiency alleviates diabetic renal lipid accumulation through regulation of Akt (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) pathway
High expression of TXNIP indicates a lower pathological grade of meningnioma, and is also associated with longer recurrence-free time.
All-trans retinoic acid plays a key role in inhibition of hepatic stellate cell activation via suppressing TXNIP expression, which reduces oxidative stress levels.
Study shows that TXNIP expression is down-regulated in new Multiple Sclerosis (MS) patients compared to controls and might be implicated in pathogenesis of the disease.
TXNIP Single nucleotide polymorphisms may individually and cumulatively affect CAD (zeige CAD ELISA Kits) risk through a possible mechanism for regulating TXNIP expression and gene-environment interactions.
Taken together, our results firstly reveal that TMAO induces inflammation and endothelial dysfunction via activating ROS (zeige ROS1 ELISA Kits)-TXNIP-NLRP3 (zeige NLRP3 ELISA Kits) inflammasome, suggest a likely mechanism for TMAO-dependent enhancement in atherosclerosis and cardiovascular risks.
The molecular characterization of porcine TXNIP gene, is described.
single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain
Foam cell-released 4-hydroxnonenal activates PPARdelta (zeige PPARD ELISA Kits) in Vascular endothelial cells, leading to increased TXNIP expression and consequently to senescence.
Here the authors demonstrate that thioredoxin-interacting protein (Txnip), which regulates glucose homeostasis in mammals, binds to fructose transporters and promotes fructose absorption by the small intestine.
TXNIP-NFYA (zeige NFYA ELISA Kits)-SREBP2 (zeige SREBF2 ELISA Kits)/miR (zeige MLXIP ELISA Kits)-33a-AMPKalpha (zeige GRK4 ELISA Kits)/CROT (zeige CROT ELISA Kits)/CPT1 (zeige CPT1A ELISA Kits)/HADHB (zeige HADHB ELISA Kits) pathway is conserved in mouse, rat, and human cardiomyocytes and regulates myocardial beta-oxidation.
results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP-NLRP3 (zeige NLRP3 ELISA Kits) inflammasome pathway.
proteomic and functional analyses demonstrated that Txnip inhibits glucose transport through direct binding to glucose transporter 1 (GLUT1 (zeige SLC2A1 ELISA Kits)). An ex vivo analysis of perfused hearts further demonstrated that the enhanced functional reserve afforded by deletion of Txnip was associated with myocardial glucose utilization during beta-adrenergic stimulation.
Thrombin (zeige F2 ELISA Kits) activates reactive oxygen species (ROS (zeige ROS1 ELISA Kits))/thioredoxin (zeige TXN ELISA Kits) binding protein (TXNIP)/NLRP3 (zeige NLRP3 ELISA Kits) signaling in BV2 (zeige DNAH9 ELISA Kits) microglia cells, which may indicate a mechanism that pro-inflammatory and pro-apoptotic contributes to the development of intracerebral hemorrhage (ICH (zeige ACE ELISA Kits)).
TxNIP appears to be an important factor in FFA-induced ROS (zeige ROS1 ELISA Kits) generation and insulin (zeige INS ELISA Kits) resistance in skeletal muscle cells
Glucose exerts strong stimulatory effects on activation histone marks while having inhibitory effects on repression marks in the promoter of the TXNIP gene, and this was associated with a marked increase in expression of the proinflammatory gene in kidney.
Diabetes induces TXNIP expressions at mRNA levels, but shows the opposite effect on GS.
regulates thioredoxin to play an important role in the preservation of cellular viability
thioredoxin interacting protein
, Thioredoxin-interacting protein
, thioredoxin binding protein 2
, thioredoxin-binding protein 2
, thioredoxin-interacting protein
, upregulated by 1,25-dihydroxyvitamin D-3
, vitamin D3 up-regulated protein 1
, hyperlipidemia 1
, thioredoxin binding protein-2