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Lhx2 (zeige LHX2 Antikörper) may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3b.
lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS.
Six3 in a small population of progenitors expressing Six3-Cre at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice.
variations in Six3 dosage result in different forms of Holoprosencephaly
SIX3 and SIX6 (zeige SIX6 Antikörper) play distinct but compensatory roles in regulating transcription of gonadotrope-specific genes as gonadotrope cells differentiate.
Sox2 directly activates the Six3 forebrain enhancer.
Six3OS regulates Six3 activity in developing retina by a mechanism via which promoter-associated long non-coding RNAs can modulate the activity of their associated protein coding genes during development.
It was shown that Six3 is necessary for ependymal cell maturation during postnatal stages of brain development. In its absence, ependymal cells fail to suppress radial glia characteristics.
Neuroretina specification requires Six3-mediated suppression of Wnt8b (zeige WNT8B Antikörper) a few hours later at the 6- to 8-somite stage.
Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.
role of expression with pax6 (zeige PAX6 Antikörper) on haploinsufficient lens phenotype
Six 3 and Six 6 (zeige SIX6 Antikörper) are differentially required during forebrain development; gene expression in brain
May be involved in visual system development.
sine oculis homeobox homolog 6
, homeobox protein SIX3
, sine oculis homeobox homolog 3
, sine oculis-related homeobox 3 homolog