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anti-Mouse (Murine) CSE1L Antikörper:
anti-Human CSE1L Antikörper:
anti-Rat (Rattus) CSE1L Antikörper:
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Human Monoclonal CSE1L Primary Antibody für IF, IHC (p) - ABIN560494
Tsao, Tsai, Tung, Chen, Yue, Liao, Wang, Jiang: Function of CSE1L/CAS in the secretion of HT-29 human colorectal cells and its expression in human colon. in Molecular and cellular biochemistry 2009
Show all 10 Pubmed References
Human Monoclonal CSE1L Primary Antibody für IF, ELISA - ABIN560487
Roy, Khan, Islam, Prieto, Majid: Interdependency of cystathione ?-lyase and cystathione ?-synthase in hydrogen sulfide-induced blood pressure regulation in rats. in American journal of hypertension 2011
an important role for Cas proteins in cell-cell adhesion signaling in development
serum phospho-CSE1L is useful for early detecting the efficacy of targeted therapy in initial treatment.
CSE1L knockdown reduced Ras-induced metastasis of B16F10 melanoma cells in C57BL/ (zeige HRAS Antikörper)6 mice. v-H-Ras expression altered the cellular trafficking of CSE1L and increased CSE1L secretion.
Serum cellular apoptosis susceptibility protein may have a role in progression of metastatic colorectal cancer
CSE1L/CAS has a role in proliferation and apoptosis [review]
Cse1l is a negative regulator of cystic fibrosis transmembrane conductance regulator (zeige CFTR Antikörper)-dependent fluid secretion.
CSE1L expression was correlated with MSH6 (zeige MSH6 Antikörper) expression in tumor samples and was associated with poor prognosis in patients with osteosarcoma. Taken together, our results demonstrate that the CSE1L-MSH6 (zeige MSH6 Antikörper) axis has an important role in osteosarcoma progression.
CSE1L appears to be critical for the nuclear import of certain key repressive proteins. Indeed, NOVA1 (zeige NOVA1 Antikörper), HDAC1 (zeige HDAC1 Antikörper), HDAC2 (zeige HDAC2 Antikörper), and HDAC8 (zeige HDAC8 Antikörper), genes known as silencing factors, became delocalized into cytosol upon CSE1L depletion.
The combination of CTNB1, XPO2, and CAPG (zeige NCAPG Antikörper) achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes. We developed two uterine aspirate-based signatures to diagnose Endometrial cancer and classify tumors in the most prevalent histologic subtypes. This will improve diagnosis and assist in the prediction of the optimal surgical treatment
Our data suggest a previously unanticipated link between CAS and integrin beta1 signaling which correlates with an aggressive hepatocellular carcinoma phenotype.
CSE1L knockdown by shRNA inhibited protein, resulting in decreased cell proliferation, reduced colony formation in soft agar, and induction of apoptosis. CSE1L protein is expressed early and across all stages of colorectal carcinoma (CRC (zeige CALR Antikörper)) development. shRNA knockdown of CSE1L was associated with inhibition of tumorigenesis in CRC (zeige CALR Antikörper) cells. CSE1L may represent a potential target for treatment of CRC (zeige CALR Antikörper).
Data suggest that CAS overexpression in thyroid carcinoma depends on the subtype and the disease stage. Our findings also indicate that CAS maintains papillary thyroid cell proliferation and survival.
There is a relationship between nuclear CSE1L overexpression and distant metastasis in breast cancer.
CAS plays contrasting roles in proliferation and apoptosis
hCAS/CSE1L is responsible for controlling the homologous recombinational repair activity by directly interacting with RAD51 (zeige RAD51 Antikörper).
nuclear CSE1L is mainly non-phosphorylated CSE1L and is involved in gene regulation and cytoplasmic CSE1L is mainly phosphorylated CSE1L and is involved in cytoplasmic signaling regulation in melanocytic tumorigenesis.
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.
, Importin-alpha re-exporter
, CSE1 chromosome segregation 1-like (yeast)
, CSE1 chromosome segregation 1-like protein
, CSE1 chromosome segregation 1-like
, chromosome segregation 1-like protein
, importin-alpha re-exporter
, cellular apoptosis susceptibilit
, cellular apoptosis susceptibility
, exportin 2
, cellular apoptosis susceptibility protein