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Subcellular localization of APC8 is regulated during male gametophyte development.
Results identified CDC23 as a miR (zeige MLXIP Proteine)-34c-regulated target that could be responsible for the miR (zeige MLXIP Proteine)-34c-induced cell cycle arrest.
CDC23 is a critical regulator of cell cycle (zeige C13orf15 Proteine) and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender.
Cdc20 (zeige CDC20 Proteine) requires APC3 and APC8 to bind and activate the APC (zeige APC Proteine)/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 (zeige ANAPC10 Proteine) is crucial for the destruction of cyclin B1 (zeige CCNB1 Proteine) and securin (zeige PTTG1 Proteine), but not cyclin A (zeige CCNA2 Proteine)
We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 (zeige CDC16 Proteine) and APC8/CDC23 which are known to be key function elements.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
cell division cycle protein 23
, cell division cycle protein 23 homolog
, cell division cycle 23 homolog (S. cerevisiae)
, CDC23 (cell division cycle 23, yeast, homolog)
, Cell division cycle protein 23 homolog
, cell division cycle protein 23 homolog-like
, anaphase-promoting complex subunit 8
, cyclosome subunit 8
, anaphase promoting complex subunit 8
, cell division cycle 23 homolog