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CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC (zeige FUT1 Proteine)), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells.
CD70 (zeige CD70 Proteine) reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
CD27-dependent CD8 (zeige CD8A Proteine)(+) T cell priming and differentiation are shaped by the efficiency of NK responses to virus infection.
HSCs appear to maintain expression of CD27 after hematopoietic injury when Kit expression is downregulated.
Mature CD27low NK cells promote allograft survival under costimulatory blockade conditions by regulating alloreactive memory CD8+ T-cell responses in T-bet dependent manner.
identify an IL-17 (zeige IL17A Proteine)-dependent lymphoid/myeloid cross-talk involving CD27(-) gammadelta T cells and small peritoneal macrophages that promotes ovarian tumor cell growth and thus counteracts cancer immunosurveillance
memory CD8 (zeige CD8A Proteine) T cells, generated through priming with CD27 agonists, proliferated more extensively than did 4-1BB (zeige TNFRSF9 Proteine)-generated memory cells, but these cells failed to persist.
the central role played by CD27/70 during secondary CD8 (zeige CD8A Proteine)(+) T-cell activation to a peptide Ag, and identify sCD70 as an immunotherapeutic adjuvant for antitumor immunity.
under conditions of constitutive CD70 (zeige CD70 Proteine) expression reflecting chronic immune activation, the CD27/CD70 (zeige CD70 Proteine) system inhibits OC differentiation and favors DC differentiation
mTECs and DCs form dedicated niches in the thymic medulla, in which CD27-CD70 (zeige CD70 Proteine) co-stimulation rescues developing Treg cells from apoptosis, subsequent to Foxp3 (zeige FOXP3 Proteine) induction by TCR and CD28 (zeige CD28 Proteine) signals.
The authors observed differential expression of CD95(Fas (zeige FAS Proteine)) in CD27(+) B-cells from cirrhotic patients that was inversely correlated with peripheral CD27(+) B-cell frequency. They conclude that peripheral CD27(+) memory B-cells in cirrhosis exhibit increased sensitivity to Fas (zeige FAS Proteine)-induced apoptosis in an activation-dependent manner to which endotoxin contributes, associated with reduced frequency of circulating memory B-cells.
Preclinical testing supports the safety and efficacy of a CD27-containing CAR targeting CD70 (zeige CD70 Proteine)-expressing tumors
Crystal structure of CD27 in complex with a neutralizing noncompeting antibody has been reported.
High CD27 expression is associated with B-cell Lymphoma.
activated CD70 (zeige CD70 Proteine)-expressing lymphocytes may trigger CD27 on AML (zeige RUNX1 Proteine) blasts or stem/progenitor cells
the CD70 (zeige CD70 Proteine)-CD27 pathway appears to be a crucial component of EBV-specific T cell immunity and more generally for the immune surveillance of B cells and may be a target for immunotherapy of B cell malignancies.
This study demonstrates increased level of sCD27 in patients with active vitiligo (zeige MITF Proteine).
This study demonstrated that Soluble CD27 in cerebrospinal fluid of patients with Clinically Isolated Syndrome was associated with multiple sclerosis diagnosis and a high relapse rate.
HCV infection increased the frequency of CD4 (zeige CD4 Proteine)+CXCR5 (zeige CXCR5 Proteine)+ T cells and decreased the frequency of CD27+IgG+ B cells. CD4 (zeige CD4 Proteine)+CXCR5 (zeige CXCR5 Proteine)+ T cells activated CD27+IgG+ B cells via the secretion of IL-21 (zeige IL17C Proteine).
Novel mutations in TNFRSF7/CD27 cause EBV-associated lymphoproliferative disease/hemophagocytic lymphohistiocytosis, Hodgkin lymphoma, uveitis, and recurrent infections.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
tumor necrosis factor receptor superfamily, member 7
, CD27 antigen
, CD27L receptor
, CD antigen 27
, T-cell activation antigen CD27
, tumor necrosis factor receptor superfamily member 7
, T cell activation antigen S152