The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq, Jul 2008].
PROCR
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
AM, ADA, IA, ScA
Kwak, Han, Bae: "Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo." in: Fitoterapia, Vol. 100, pp. 179-86, (2015) (PubMed).
Ku, Kim, Bae: "Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo." in: Inflammation, Vol. 37, Issue 2, pp. 435-42, (2014) (PubMed).
Fink, Busch, Bourgeois, Schwarz, Wolf, Zirlik, Peter, Bode, von Zur Muhlen: "Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation?" in: PLoS ONE, Vol. 8, Issue 2, pp. e53103, (2013) (PubMed).
Turner, Lavstsen, Berger, Wang, Petersen, Avril, Brazier, Freeth, Jespersen, Nielsen, Magistrado, Lusingu, Smith, Higgins, Theander: "Severe malaria is associated with parasite binding to endothelial protein C receptor." in: Nature, Vol. 498, Issue 7455, pp. 502-5, (2013) (PubMed).
Fukudome, Esmon: "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor." in: The Journal of biological chemistry, Vol. 269, Issue 42, pp. 26486-91, (1994) (PubMed).
Aliase für PROCR Proteine
protein C receptor (PROCR) Proteine protein C receptor (Procr) Proteine protein C receptor, endothelial (Procr) Proteine AI325044 Proteine CCCA Proteine Ccca Proteine CCD41 Proteine Ccd41 Proteine EPCR Proteine Epcr Proteine PROCR Proteine