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PRMT5 Proteine

(Protein Arginine Methyltransferase 5 (PRMT5))
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).

8 Treffer

custom-made PRMT5 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7552219
 
PRMT5 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Pubmed 1 reference
Produktnummer ABIN1316333
 
PRMT5 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Produktnummer ABIN1316335
 
PRMT5 Spezies: Human Wirt: Baculovirus Recombinant EAA, ScA
Produktnummer ABIN2669658
 
PRMT5 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant WB, ELISA, SDS
Produktnummer ABIN7579003
 
custom-made PRMT5 Spezies: Human Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, ELISA, SDS
Produktnummer ABIN3089077
 
PRMT5 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2729673
 
Rockland 009-001-t05s PRMT5 Spezies: Human Wirt: Insect cells (Sf9) Recombinant >95% WB
Produktnummer ABIN6700421
Rockland Original
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • ELISA
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • SDS-PAGE (SDS)
    • Antibody Production (AbP)
    • Enzyme Activity Assay (EAA)
    • Screening Assay (ScA)
    • Standard (STD)
  • Reaktivität
    • Human
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • HEK-293 Cells
    • Wheat germ
    • Baculovirus
    • Cell-free protein synthesis (CFPS)
    • Escherichia coli (E. coli)
    • Insect cells (Sf9)
  • Bindungsspezifität
    • AA 1-637
    • AA 531-637
    • Transcript Variant 1
  • Konjugat
    • GST tag
    • His tag
    • DYKDDDDK Tag
    • Myc-DYKDDDDK Tag
    • Strep Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • custom-made
  • Hersteller
    • antibodies-online
    • Active Motif
    • OriGene
    • Rockland

Aktuelle Publikationen für unsere PRMT5 Proteine

Kanamaluru, Xiao, Fang, Choi, Kim, Veenstra, Kemper: "Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner." in: Molecular and cellular biology, Vol. 31, Issue 7, pp. 1540-50, (2011) (PubMed).

Aliase für PRMT5 Proteine

protein arginine methyltransferase 5 (PRMT5) Proteine
protein arginine N-methyltransferase 5 (Prmt5) Proteine
protein arginine methyltransferase 5 (Prmt5) Proteine
protein arginine methyltransferase 5 (prmt5) Proteine
protein arginine methyltransferase 5 L homeolog (prmt5.L) Proteine
putative arginine N-methyltransferase, type II (PRMT5) Proteine
Skb1 family protein (prmt5) Proteine
protein arginine N-methyltransferase 5 (LOC100115766) Proteine
Protein arginine N-methyltransferase 5 (prmt-5) Proteine
DDBDRAFT_0187422 Proteine
DDBDRAFT_0235403 Proteine
DDB_0187422 Proteine
DDB_0235403 Proteine
HRMT1L5 Proteine
hrmt1l5 Proteine
hsl7 Proteine
IBP72 Proteine
ibp72 Proteine
JBP1 Proteine
Jbp1 Proteine
jbp1 Proteine
NV18830 Proteine
si:zc14a17.2 Proteine
SKB1 Proteine
Skb1 Proteine
skb1 Proteine
SKB1Hs Proteine
skb1hs Proteine
wu:fb95f10 Proteine
zgc:110669 Proteine
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