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Human SNAP25 Protein expressed in HEK-293 Cells - ABIN2732308
Brinkmalm, Brinkmalm, Honer, Moreno, Jakobsson, Mallucci, Zetterberg, Blennow, Öhrfelt: Targeting synaptic pathology with a novel affinity mass spectrometry approach. in Molecular & cellular proteomics : MCP 2014
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Our findings provide in vivo functional evidence showing a critical role of SNAP-25 dysfunction on synaptic transmission, which contributes to the developmental of schizophrenia.
Snap-25-null mutant neurons degenerate after 4 days in vitro and contain fewer dense-core vesicles.
a mouse mutant engineered to express normal levels of SNAP-25 but only SNAP-25a shows metabolic disease.
The function of synaptotagmin-1 (syt-1 (zeige SYT1 Proteine)):soluble NSF attachment protein (zeige NAPG Proteine) receptor (SNARE (zeige VTI1B Proteine)) interactions during neurotransmission remains unclear.
proteins, such as syntaxin-1, Munc18-1, or SNAP-25, modulate alpha-synuclein neuropathy and/or are dysregulated in Alzheimer's disease, understanding this type of neurodegeneration may provide new links between synaptic defects and neurodegeneration in humans
Study showed that SNAP25 is synthesized in the motor nerve endings and that the level of SNAP25 mRNA affects the activity of exocytosis of the neurotransmitter
Data demonstrate a role for SNAP-25 in controlling PSD-95 (zeige DLG4 Proteine) clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.
Data suggest that porosome-associated proteins SNAP25, TREK-1 (zeige KCNK2 Proteine), syntaxin-1A (zeige STX1A Proteine), and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin (zeige INS Proteine)-secreting porosomes in cell membrane of live cells.
we demonstrate that Syb2 (zeige VAMP2 Proteine) and SNAP25 mediate the vesicular release of BDNF (zeige BDNF Proteine) in axons and dendrites of cortical neurons
The extreme C terminus of SNAP25 is a critical region for the GBetaGamma-SNARE (zeige VTI1B Proteine) interaction.
report some evidence supporting the association of SNAP25 to Attention Deficit/Hyperactivity Disorder
Single nucleotide polymorphism in SNAP-25 gene is associated with Attention deficit hyperactivity disorder.
Findings indicate that lower SNAP-25 in ventromedial caudate in schizophrenia is primarily due to less SNAP-25A, and that the remaining SNAP-25 is associated with greater protein-protein interaction with syntaxin. The absence of a link to recent treatment effects in the human samples, or to administration of antipsychotic drugs in rats suggests the findings are illness- and not treatment-related.
Allelic variation of SNAP25 modulates development and plasticity of the prefrontal-limbic network and a shared genetic vulnerability between Bipolar Disorder and Schizophrenia.
SH3BP5 (zeige SH3BP5 Proteine), LMO3 (zeige LMO3 Proteine), and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features.
show that FOXC1 (zeige FOXC1 Proteine) regulates the expression of RAB3GAP1 (zeige RAB3GAP1 Proteine), RAB3GAP2 and SNAP25
study demonstrated that miR (zeige MLXIP Proteine)-27a and -b, which are widely expressed in host cells, suppress SNAP25 and TXN2 (zeige TXN2 Proteine) expression through posttranscriptional gene silencing.
Data suggest that A-syn (zeige FYN Proteine) (alpha-synuclein) promotes SNARE (zeige NAPA Proteine)-dependent vesicle docking; phosphatidylserine (PS) removal from t-SNARE (zeige NAPA Proteine)-bearing vesicles causes A-syn (zeige FYN Proteine) to inhibit vesicle docking; PS removal from v-SNARE (zeige VTI1B Proteine)-bearing vesicles promotes vesicle docking; the C-terminal 45 residues of A-syn (zeige FYN Proteine) are required for promotion of vesicle docking. (Here, t-SNARE (zeige NAPA Proteine) is SNAP-25; v-SNARE (zeige VTI1B Proteine) is VAMP2 (zeige VAMP2 Proteine).)
our data indicate that the expression of SNAP25 is crucial for dendrite formation and is associated with the effects of targeted chemotherapy. The detection of SNAP25 expression in MB cells may thus be essential for the chemotherapeutic application of Ara (zeige FOXC1 Proteine)-C.
Robust association of the rs3746544 SNP and ASD (zeige ARSD Proteine), in both allele and haplotype-based analyses, was observed in Iranian population.
In individual chromaffin cells, we tracked conformational changes in SNAP25 by total internal reflection fluorescence resonance energy transfer (FRET) microscopy while exocytotic catecholamine release from single vesicles was simultaneously recorded
dynamic experiments using TIRFM revealed that attenuation of cortical F-actin movement clearly diminishes the mobility of SNAP-25 clusters.
Stable syntaxin/SNAP-25 dimers are a central principle of the SNARE (zeige NAPA Proteine) assembly pathway underlying regulated exocytosis.
microdomains carrying syntaxin1 (zeige STX1A Proteine)/SNAP-25 and different types of calcium channels act as the sites for physiological granule fusion in "in situ" chromaffin cells
These data demonstrate a differential ability of SNAP-25 homlog to support neuronal function.
data indicate that SNARE (zeige NAPA Proteine) proteins VAMP-2 (zeige VAMP2 Proteine) and SNAP-25 play an essential role in daughter blastomere apposition, possibly via the delivery of components that promote the cell-to-cell adhesion required for the successful completion of cytokinesis
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
synaptosomal-associated protein 25
, super protein
, synaptosomal-associated 25 kDa protein
, synaptosomal-associated protein, 25 kDa
, GENA 70
, blind drunk
, resistance to inhibitors of cholinesterase 4 homolog
, synaptosomal associated protein-25
, synaptosomal-associated protein 25 isoform SNAP25B
, synaptosomal-associated 25kD protein