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anti-Mouse (Murine) DACT1 Antikörper:
anti-Human DACT1 Antikörper:
anti-Rat (Rattus) DACT1 Antikörper:
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Mouse (Murine) Polyclonal DACT1 Primary Antibody für WB - ABIN2473224
Suriben, Kivimäe, Fisher, Moon, Cheyette: Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. in Nature genetics 2009
Dapper1 attenuates hepatic gluconeogenesis and lipogenesis in Ttype 2 diabetes.
Dpr1 promotes the ubiquitination of Dvl2 (zeige DVL2 Antikörper) by pVHL (zeige VHL Antikörper) and mediates the protein aggregate-elicited autophagy initiation
Expression analysis of Dact1-LacZ (zeige GLB1 Antikörper) show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues.
These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 (zeige DVL1 Antikörper) and possibly Disrupted in Schizophrenia-1 (zeige DISC1 Antikörper), in the formation of synapses on cortical interneuron dendrites.
Depletion of Dapper-1 and dishevelled-2 (zeige DVL2 Antikörper) in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 (zeige DVL2 Antikörper) and that activity of both Dapper-1 and dishevelled-2 (zeige DVL2 Antikörper) is essential for activating canonical Wnt (zeige WNT2 Antikörper) signaling.
conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl (zeige DVL1 Antikörper).
Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages.
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled (zeige DVL2 Antikörper) activity and leads to posterior malformation in mice.
This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac (zeige AKT1 Antikörper)
Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis
frd1 is expressed in the developing brain and mesoderm.
two Dvl (zeige DVL2 Antikörper)-associated paralogs, Dpr1 and Dpr2 (zeige DACT2 Antikörper), participate in distinct Wnt (zeige WNT2 Antikörper)-dependent developmental processes
target of beta-catenin (zeige CTNNB1 Antikörper) and/or an unknown downstream effector in development
Findings suggest that the DACT1 c.1256G>A nonsense variant is causative of a specific genetic syndrome with features overlapping Townes-Brocks syndrome.
An inhibitory role for DACT1 in leukemogenesis.
Dact1 is up-regulated by TGF-beta1 (zeige TGFB1 Antikörper), inducing apoptosis in mesangial cells.
The simultaneous methylation of DACT1 and DACT2 (zeige DACT2 Antikörper) may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt (zeige WNT2 Antikörper)/beta catenin (zeige CTNNB1 Antikörper) signaling.
our results suggested that DACT1 was upregulated during human placenta development.
There was no statistical difference between groups concerning DACT1 and DACT2 (zeige DACT2 Antikörper) either in promoter hypermethylation or transcript levels. Age was associated with DACT2 (zeige DACT2 Antikörper) promoter hypermethylation, especially over 56 years old.
Overexpression of Dapper-1 allows the translocation of MIZ-1 (zeige ZBTB17 Antikörper) from the nucleus to the cytoplasm.
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.
dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
, dapper 1
, dapper, antagonist of beta-catenin
, dapper, antagonist of beta-catenin, homolog 1
, dapper homolog 1-like
, dapper antagonist of catenin 1
, dapper homolog 1
, frodo homolog
, thymus expressed gene 3
, thymus-expressed novel gene 3 protein
, dishevelled-interacting protein
, frodo 1
, hepatocellular carcinoma novel gene 3 protein
, heptacellular carcinoma novel gene 3
, dapper 1-B
, dapper homolog 1, antagonist of beta-catenin