DACT1 Antikörper (AA 410-525) (HRP)

Produktnummer ABIN7149491

Produktdetails anti-DACT1 Antikörper (HRP)

Target: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Bindungsspezifität: AA 410-525

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DACT1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Dapper homolog 1 protein (410-525AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DACT1

Target: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Andere Bezeichnung: DACT1 (DACT1 Produkte)

Synonyme: XDpr antikoerper, dpr1 antikoerper, frodo antikoerper, hdpr1 antikoerper, Dapper antikoerper, thyex3 antikoerper, dapper1 antikoerper, MGC89695 antikoerper, frd1 antikoerper, frodo1 antikoerper, 4921528D17Rik antikoerper, AI115603 antikoerper, DAPPER antikoerper, DAPPER1 antikoerper, FRODO antikoerper, Frd1 antikoerper, Frodo1 antikoerper, MDpr1 antikoerper, MTNG3 antikoerper, THYEX3 antikoerper, DPR1 antikoerper, HDPR1 antikoerper, DACT1 antikoerper, RGD1564008 antikoerper, XDpr1a antikoerper, dact1 antikoerper, dpr antikoerper, XDpr1b antikoerper, dishevelled-binding antagonist of beta-catenin 1 antikoerper, dishevelled binding antagonist of beta catenin 1 antikoerper, dishevelled-binding antagonist of beta-catenin 1 L homeolog antikoerper, dishevelled-binding antagonist of beta-catenin 1 S homeolog antikoerper, dact1 antikoerper, Dact1 antikoerper, DACT1 antikoerper, dact1.L antikoerper, dact1.S antikoerper

Hintergrund:

Background: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism, the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2, the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

Aliases: Dact antibody, dact1 antibody, DACT1_HUMAN antibody, Dapper antagonist of beta catenin homolog 1 antibody, Dapper antagonist of catenin 1 antibody, Dapper antibody, Dapper homolog 1 antibody, DAPPER1 antibody, Dpr antibody, Dpr1 antibody, Frd antibody, Frodo antibody, hDPR1 antibody, Hepatocellular carcinoma novel gene 3 protein antibody, Heptacellular carcinoma novel gene 3 antibody, HNG3 antibody, MTNG3 antibody, Thyex3 antibody

UniProt: Q9NYF0

Pathways: Positive Regulation of fat Cell Differentiation