anti-Cathepsin H (CTSH) Antikörper

Human Cathepsin H (CTSH) Interaktionspartner

1. Study presents the crystal structures of human procathepsin H at 2.00 A and 1.66 A resolution. These structures allow us to explore in detail the molecular basis for the inhibition of the mature domain by the prodomain. Comparison with cathepsin H structure reveals how mini-chain reorients upon activation. Results demonstrate that procathepsin H is not auto-activated but can be trans-activated by cathepsin L.

2. the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts).

3. Especially, rs3825932 in CTSH has integrative functional evidence supporting the association with type 1 diabetes mellitus.

4. p41 fragment is also shown to reduce the secretion of interleukin-12 (IL-12/p70) during the subsequent maturation of treated dendritic cells.

5. In conclusion, CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to proliferative diabetic retinopathy and two-step progression of diabetic retinopathy on the ETDRS scale accordingly.

6. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.

7. The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D

8. Quantification of immunohistochemistry showed that there is no difference in the global expression of CTSD, CTSH and CTSK between asthmatics and non-asthmatics.

9. CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength

10. The processing of procathepsin H is an autocatalytic, multistep process proceeding from an inactive 41kDa pro-form, through a 30kDa intermediate form, to the 28kDa mature form.

11. CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression.

12. These data indicate that cathepsins B, L and S may act as cell-death mediators in in monocytic cells infected with ICP4 and Us3 deletion mutant herpes simplex virus type 1.

13. involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes

14. production of cathepsins B and H by tumor cells along with concomitant decrease of their inhibitor, cystatin C, in the CSF might contribute in the process of metastasis and spread of the cancer cells in the leptomeningeal tissues

15. Cathepsin H could contribute to the transformation of LDL to an atherogenic moiety; the process might involve a self-sustaining amplifying circle.

16. kinetic data on substrates hydrolysis and enzyme inhibition show the role of the mini-chain as a framework for transition state stabilization of free alpha-amino groups of substrates and as a structural barrier for endopeptidase-like substrate cleavage.

17. AKR1B1 and CTSH may be good markers for prediction of sensitivity to certain drugs

18. cathepsin H is involved in maturation of the biologically active surfactant associated protein B

19. cathepsin H has a role in progression of colorectal cancer that is distinct from that of cathepsins B and L

20. A general defect in napsin A or cathepsin H expression or activity was not the specific cause for abnormal surfactant accumulation in juvenile pulmonary alveolar proteinosis

Mouse (Murine) Cathepsin H (CTSH) Interaktionspartner

1. CatH deficiency impaired toll-like receptor 3-mediated activation of interferon regulatory factor 3 and consequent secretion of IFN-beta

2. The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D

3. Cathepsin H knockout mice show reduced brain levels of (Met)enkephalin and galanin.

4. cathepsin H is involved in the SP-B production.

5. CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression.

6. In two mouse models of pancreatic islet cancer, deletion of CtsH reduced tumor progression; mechanisms involved impaired angiogenic switching from premalignant state, poor vascularization of tumors, and increased apoptosis.

7. In proteolipid protein transgenic mice cathepsin H is upregulated primarily in microglia/macrophages of white matter.

8. Presence of cathepsin H and (bone morphogenetic protein 4)BMP4 in lung or other developing organs suggest that cathepsin H regulates BMP4 proteolysis in morphogenesis.