POLH Produkte
(Polymerase (DNA Directed), eta (POLH))
Kategorien
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].
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Ausgewählte POLH Kategorien
POLH Antikörper
High quality antibodies with extensive validation data.
POLH Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene POLH Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7150247
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7252888
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IF
Validierungen
- (3)
Kat. Nr.
ABIN7259837
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene POLH Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7555014
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7565103
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315646
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren POLH Produkten
: "c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks." in: Molecular biology of the cell, Vol. 23, Issue 10, pp. 1943-54, (2012) (PubMed).: "Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication." in: The Journal of cell biology, Vol. 191, Issue 5, pp. 953-66, (2010) (PubMed).
: "Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae." in: Nucleic acids research, Vol. 35, Issue 3, pp. 881-9, (2007) (PubMed).
: "Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae." in: Journal of molecular biology, Vol. 366, Issue 4, pp. 1074-86, (2007) (PubMed).
: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).
: "Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions." in: The EMBO journal, Vol. 20, Issue 24, pp. 7303-12, (2001) (PubMed).
: "Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene." in: Oncogene, Vol. 19, Issue 41, pp. 4721-8, (2000) (PubMed).
: "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta." in: Nature, Vol. 399, Issue 6737, pp. 700-4, (1999) (PubMed).
: "hRAD30 mutations in the variant form of xeroderma pigmentosum." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 263-5, (1999) (PubMed).
Synonyme und alternative Namen zu POLH
polymerase (DNA directed), eta S homeolog (polh.S), DNA polymerase eta (POLH), polymerase (DNA directed), eta (polh), DNA polymerase eta (Tb10.70.6190), putative DNA polymerase eta (LINJ_21_0690), polymerase (DNA directed), eta (Polh), DNA polymerase eta (LOC100443019), DNA polymerase eta (polh), DNA polymerase eta (Polh), polymerase (DNA directed), eta (RAD 30 related) (Polh), fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642Bezeichner auf Proteinebene für POLH
- DNA-directed DNA polymerase eta
- DNA polymerase eta
- polymerase (DNA directed), eta
- DNA polymerase eta-like
- polymerase eta
- RAD30 homolog A
- xeroderma pigmentosum variant type protein
- polymerase (DNA directed), eta (RAD 30 related)
- xeroderma pigmentosum variant type protein homolog
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