POLI Produkte
(Polymerase (DNA Directed) iota (POLI))
Kategorien
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
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Ausgewählte POLI Kategorien
POLI Antikörper
High quality antibodies with extensive validation data.
POLI Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene POLI Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
- (5)
Kat. Nr.
ABIN564869
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, IF, ICC
Validierungen
- (3)
Kat. Nr.
ABIN6264338
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (2)
Kat. Nr.
ABIN7150251
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene POLI ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6203766
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene POLI Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124512
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315648
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315650
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren POLI Produkten
: "DNA polymerase ι is acetylated in response to SN2 alkylating agents." in: Scientific reports, Vol. 9, Issue 1, pp. 4789, (2019) (PubMed).: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).
: "Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication." in: Molecular and cellular biology, Vol. 35, Issue 4, pp. 699-715, (2015) (PubMed).
: "Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin." in: Nature communications, Vol. 5, pp. 5437, (2014) (PubMed).
: "DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity." in: Nucleic acids research, Vol. 40, Issue 1, pp. 170-80, (2011) (PubMed).
: "Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation." in: Journal of nucleic acids, Vol. 2010, pp. 750296, (2010) (PubMed).
: "DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11552-7, (2009) (PubMed).
: "Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations." in: Cancer research, Vol. 67, Issue 7, pp. 3018-26, (2007) (PubMed).
: "The role of DNA polymerase iota in UV mutational spectra." in: Mutation research, Vol. 599, Issue 1-2, pp. 58-65, (2006) (PubMed).
: "Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template." in: The EMBO journal, Vol. 20, Issue 11, pp. 2914-22, (2001) (PubMed).
Synonyme und alternative Namen zu POLI
DNA polymerase iota (POLI), polymerase (DNA directed) iota (poli), DNA polymerase iota (LOC551219), DNA polymerase iota (AFUA_4G11140), DNA polymerase iota (LOC5568276), polymerase (DNA directed) iota (Pol-iota), polymerase (DNA directed), iota (Poli), DNA polymerase iota (Poli), GB12093, NV16187, poli, RAD3OB, RAD30B, Rad30b, wu:fc27h11, zgc:110185Bezeichner auf Proteinebene für POLI
- DNA polymerase iota
- polymerase (DNA directed) iota
- DNA polymerase iota-like
- RAD30 homolog B
- eta2
- polymerase (DNA-directed), iota
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