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PLAU Proteine

(Plasminogen Activator, Urokinase (PLAU))
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].

Gesetzte Filter:

  • Target: PLAU
  • Protein
Catalog no. Produkt Reaktivität Wirt / Klonalität Anwendung Preis & Lieferzeit
ABIN6125462
PLAU Protein (His tag) PLAU · Protein Kaninchen Escherichia coli (E. coli)
  • SDS (SDS-PAGE: Angegebene Anwendung)
  • WB (Western Blotting: Angegebene Anwendung)
628,83 € Preis anzeigen
  • 50 μg
  • 1 mg
  • 100 μg
  • 200 μg
  • 500 μg
Lieferung in 7 bis 15 Werktagen Lieferung nach: Deutschland
ABIN6125460
PLAU Protein (His tag) PLAU · Protein Huhn Escherichia coli (E. coli)
  • SDS (SDS-PAGE: Angegebene Anwendung)
  • WB (Western Blotting: Angegebene Anwendung)
628,83 € Preis anzeigen
  • 50 μg
  • 1 mg
  • 100 μg
  • 200 μg
  • 500 μg
Lieferung in 7 bis 15 Werktagen Lieferung nach: Deutschland
ABIN2735030
PLAU Protein (Transcript Variant 1) (His tag) PLAU · Protein Human HEK-293 Cells
  • AbP (Antibody Production: Angegebene Anwendung)
  • STD (Standard: Angegebene Anwendung)
469,23 € Preis anzeigen
  • 10 μg
Lieferung in 8 bis 14 Werktagen Lieferung nach: Deutschland
Protein
  • SDS (SDS-PAGE: Angegebene Anwendung)
  • WB (Western Blotting: Angegebene Anwendung)
Spezies
Kaninchen
Wirt
Escherichia coli (E. coli)
Protein-Typ
Recombinant
Reinheit
> 90 %
Produktnummer ABIN6125462
628,83 €
Zzgl. Versandkosten 20,00 € und MwSt
50 μg (Weitere Mengeneinheiten)
Lieferung nach: Deutschland
Lieferung in 7 bis 15 Werktagen
Protein
  • SDS (SDS-PAGE: Angegebene Anwendung)
  • WB (Western Blotting: Angegebene Anwendung)
Spezies
Huhn
Wirt
Escherichia coli (E. coli)
Protein-Typ
Recombinant
Reinheit
> 90 %
Produktnummer ABIN6125460
628,83 €
Zzgl. Versandkosten 20,00 € und MwSt
50 μg (Weitere Mengeneinheiten)
Lieferung nach: Deutschland
Lieferung in 7 bis 15 Werktagen
Protein
  • AbP (Antibody Production: Angegebene Anwendung)
  • STD (Standard: Angegebene Anwendung)
Spezies
Human
Wirt
HEK-293 Cells
Protein-Typ
Recombinant
Reinheit
> 95 % as determined by SDS-PAGE and Coomassie blue staining
Produktnummer ABIN2735030
469,23 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach: Deutschland
Lieferung in 8 bis 14 Werktagen

Aktuelle Publikationen für unsere PLAU Proteine

Ambrosetti, Paoletti, Bosco, Parisse, Scaini, Tagliabue, de Marco, Casalis: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).

Kim, Tirloni, Radulovic, Lewis, Bakshi, Hill, da Silva Vaz, Logullo, Termignoni, Mulenga: "Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions." in: International journal for parasitology, Vol. 45, Issue 9-10, pp. 613-27, (2015) (PubMed).

Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: "Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14219-32, (2014) (PubMed).

Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).

Sanderson-Smith, Zhang, Ly, Donahue, Hollands, Nizet, Ranson, Ploplis, Walker, Castellino: "A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection." in: PLoS pathogens, Vol. 9, Issue 7, pp. e1003469, (2013) (PubMed).

Larusch, Merkulova, Mahdi, Shariat-Madar, Sitrin, Cines, Schmaier: "Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through ?1-integrin and VEGFR2." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 3, pp. H305-20, (2013) (PubMed).

Ilkovitch, Carrio, Lopez: "uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation." in: Anticancer research, Vol. 32, Issue 10, pp. 4263-70, (2012) (PubMed).

Botkjaer, Deryugina, Dupont, Gårdsvoll, Bekes, Thuesen, Chen, Chen, Ploug, Quigley, Andreasen: "Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism." in: Molecular cancer research : MCR, Vol. 10, Issue 12, pp. 1532-43, (2012) (PubMed).

Novak, Bryer, Cheng, Nguyen, Conley, Cunningham, Xue, Sisson, You, Hornberger, Koh: "Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 3, pp. 1448-57, (2011) (PubMed).

Hosseini, Jiang, Sørensen, Jensen, Christensen, Fogh, Yuan, Andersen, Huang, Andreasen, Jensen: "Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs." in: Molecular pharmacology, Vol. 80, Issue 4, pp. 585-97, (2011) (PubMed).

Aliase für PLAU Proteine

plasminogen activator, urokinase (PLAU) Proteine
urokinase-type plasminogen activator (CpipJ_CPIJ002131) Proteine
urokinase-type plasminogen activator (CpipJ_CPIJ006543) Proteine
urokinase-type plasminogen activator (CpipJ_CPIJ013396) Proteine
urokinase-type plasminogen activator (CpipJ_CPIJ013623) Proteine
plasminogen activator, urokinase (Plau) Proteine
ATF Proteine
BDPLT5 Proteine
PLAU Proteine
QPD Proteine
u-PA Proteine
UPA Proteine
uPA Proteine
UPAM Proteine
URK Proteine
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