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anti-Mouse (Murine) PIK3CA Antikörper:
anti-Human PIK3CA Antikörper:
anti-Rat (Rattus) PIK3CA Antikörper:
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Human Monoclonal PIK3CA Primary Antibody für ICC, FACS - ABIN969555
Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. in Cancer research 2009
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Human Polyclonal PIK3CA Primary Antibody für FACS, IHC (p) - ABIN1882113
Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. in Genes & development 2002
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Human Polyclonal PIK3CA Primary Antibody für ICC, IF - ABIN4345590
McCaughan, Pole, Bankier, Konfortov, Carroll, Falzon, Rabbitts, George, Dear, Rabbitts: Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. in American journal of respiratory and critical care medicine 2010
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Human Polyclonal PIK3CA Primary Antibody für ELISA, IHC - ABIN188684
López-Knowles, Hernández, Malats, Kogevinas, Lloreta, Carrato, Tardón, Serra, Real: PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. in Cancer research 2006
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Human Polyclonal PIK3CA Primary Antibody für IF (p), IHC (p) - ABIN677198
Paul-Samojedny, Suchanek, Borkowska, Pude?ko, Owczarek, Kowalczyk, Machnik, Fila-Dani?ow, Kowalski: Knockdown of AKT3 (PKB?) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cells. in BioMed research international 2014
Human Polyclonal PIK3CA Primary Antibody für IHC, ELISA - ABIN334459
Abubaker, Bavi, Al-Haqawi, Jehan, Munkarah, Uddin, Al-Kuraya: PIK3CA alterations in Middle Eastern ovarian cancers. in Molecular cancer 2009
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High PI3k expression is associated with gastrointestinal stromal tumor.
High PI3K expression is sensitive to initial injury intensity induced by freeze damage.
excessive proliferation of endometrial epithelial cells was observed in Pik3cad/d mice. Our studies suggest that Pik3ca has a critical role in uterine gland development and female fertility
Long latency DMBA induced mouse mammary tumors reproduce the molecular profile of human luminal breast carcinomas, displaying a high incidence of activating Pik3caH1047 and loss of function Pten mutations.
Data show that the phosphoinositide 3-kinase (PI3K) inhibitor BKM120 led to a precipitous drop in DNA synthesis within 8 h of drug treatment, whereas DNA synthesis in normal tissues was less affected.
Using genetic inactivation of the growth and metabolism regulator, Pik3ca (encoding PIK3CA also known as p110alpha, alpha/+), the interplay between the maternal genome and the fetal genome on placental phenotype, was examined.
these results identify the PI3K-GSK3-SMAD1 (zeige SMAD1 Antikörper) axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
Data suggest a critical role for KDM3A (zeige KDM3A Antikörper) in the PI3K/AP-1 (zeige JUN Antikörper) oncogenic axis and propose a novel strategy for inhibition of KDM3A (zeige KDM3A Antikörper) against liver tumor development under PI3K pathway activation.
Data show that tumors lacking PSMA had less than half the abundance of type 1 insulin-like growth factor receptor (IGF-1R), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK-ERK1/2 signaling.
Both PIK3CA mutants H1047R and E545K are able to activate the AKT/mTOR pathway. An intact AKT2/mTOR complex 1 cascade is required for tumourigenesis induced by H1047R/c-Met or E545K/c-Met in the liver in mice.
Oncogenic PIK3CA alters methionine and cysteine utilization, partly by inhibiting xCT (zeige SLC7A11 Antikörper) to contribute to the methionine dependency phenotype in human breast cancer cells.
The bladder cancer cell line TCCSUP, which harbors a PIK3CA E545K mutation, was sensitive to pictilisib compared to cell lines with wild-type PIK3CA Pictilisib exhibited stronger antitumor activity in bladder cancer patient-derived xenografts models with PI3KCA H1047R mutation or amplification than the control patient-derived xenografts model
By monitoring single-cell dynamics in each of these contexts, the authors identified PI3K/Akt (zeige AKT1 Antikörper) regulation of glycolysis as a multifaceted modulator of single-cell metabolic dynamics that is required to maintain metabolic stability in proliferating cells.
results suggest that c-Jun (zeige JUN Antikörper), p38 MAPK (zeige MAPK14 Antikörper), PIK3CA/Akt (zeige AKT1 Antikörper), and GSK3 signaling involved in the effect of miR (zeige MLXIP Antikörper)-203 on the proliferation of hepatocellular carcinoma cells.
these results suggest that aspirin inhibited human uterine leiomyoma cell growth by regulating KRasp110alpha interaction. Aspirin which targeting on interaction between K-Ras (zeige HRAS Antikörper) and p110alpha may serve as a new therapeutic drug for uterine leiomyoma treatment.
PIK3CA mutation is a distinctive genetic feature of NSCLC with COPD (zeige ARCN1 Antikörper), regardless of age, smoking dose, pathological stage, and histology.
In this study of 71 patients with advanced solid tumors who had received prior treatments (86% of whom were PIK3CA mutated), 3 different dose schedules of TAK (zeige CDK9 Antikörper)-117 were evaluated. The MTD (zeige MT1E Antikörper) of TAK (zeige CDK9 Antikörper)-117 was established as 150 mg once daily and 900 mg for both intermittent (MWF/MTuW) schedules.
Results show that head and neck squamous cell carcinoma tumors with low P120CTN (zeige CTNND1 Antikörper) and PI3K pathway mutations have higher levels of MMP1 (zeige MMP1 Antikörper) compared to tumors with high P120CTN (zeige CTNND1 Antikörper) and no PI3K pathway mutations demonstrating that P120CTN (zeige CTNND1 Antikörper) downregulation and PIK3CA mutations promote MMP1 (zeige MMP1 Antikörper)-driven invasion.
Case Reports: PIK3CA mutations are present in multiple tissues of facial infiltrating lipomatosis.
p85alpha plays a tumor-suppressive role in transformation; p110alpha-selective therapeutics may be effective in the treatment of breast cancer patients with PIK3R1 loss
There are multiple conformations in equilibrium during the course of PI3K SH3 domain (zeige ITSN1 Antikörper) unfolding.
PI3K has a role in activation of 5'-AMP (zeige TMPRSS5 Antikörper)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
Production of PtdIns3P by PI3K-C2alpha (zeige PIK3C2A Antikörper) is required for acquisition of fusion competence in neurosecretion.
crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
phosphoinositide-3-kinase, catalytic, alpha polypeptide
, Phosphoinositide-3-kinase, catalytic, alpha polypeptide
, PI3-kinase subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphoinositide-3-kinase catalytic alpha polypeptide
, ptdIns-3-kinase subunit alpha
, ptdIns-3-kinase subunit p110-alpha
, serine/threonine protein kinase PIK3CA
, PI3-kinase p110 subunit alpha
, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
, ptdIns-3-kinase p110
, phosphoinositide 3-kinase catalytic subunit