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miR (zeige MYLIP Proteine)-375 directly targeted PDK1 (zeige PDK1 Proteine) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.
our results offer significant insight into how PIK3CA (zeige PIK3CA Proteine) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (zeige PIK3CA Proteine)/PDK1 (zeige PDK1 Proteine) and TGFb (zeige TGFB1 Proteine) signaling in advanced HNSCC patients with PIK3CA (zeige PIK3CA Proteine) amplification
Ribociclib, in combination with GSK2334470 or the PI3Kalpha (zeige PIK3CA Proteine) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (zeige PIK3CA Proteine)-PDK1 (zeige PDK1 Proteine) signaling pathway in mediating acquired resistance to CDK4/6 (zeige CDK4 Proteine) inhibitors.
Decreased PDK1 (zeige PDK1 Proteine) protein expression in A2058 cells.
Together these results indicate a strong potential regulatory role for PDK1 (zeige PDK1 Proteine) in OC stimulatory pathways (Akt (zeige AKT1 Proteine), ERK (zeige EPHB2 Proteine)) and autophagy induction (via mTORC1), which may contribute to the OC phenotype in Paget's disease of bone.
It targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT (zeige AKT1 Proteine).
High (zeige PDK1 Proteine)ly expressed PDK1 could promote cell invasion and secretion of IL-1beta and IL-6 in human rheumatoid arthritis s (zeige PDK1 Proteine)ynovial (zeige PDK1 Proteine)MH7A c (zeige RPS6KA3 Proteine)ells. Inhib (zeige RPS6KA3 Proteine)ition of RSK2 reduced the PDK (zeige ASF1A Proteine)1-induced cell invasion and cytokines secretion (zeige PDK1 Proteine) in M (zeige RPS6KA3 Proteine)H7A cells. In response to TNF-alpha, PDK1 could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB.
In cancer cells resistant to PI3Kalpha inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2.
Results suggest that Ser (zeige SIGLEC1 Proteine)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (zeige PDK1 Proteine)-PKCtheta (zeige PRKCQ Proteine);-mediated T cell activation.
Elevated expression of PDK1 (zeige PDK1 Proteine) was an independent negative prognostic factor of gastric carcinoma.
miR (zeige MLXIP Proteine)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (zeige PDK1 Proteine).
our results offer significant insight into how PIK3CA (zeige PIK3CA Proteine) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 and TGFb (zeige TGFB1 Proteine) signaling in advanced HNSCC patients with PIK3CA (zeige PIK3CA Proteine) amplification
PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of asymmetric cell division and the Notch (zeige NOTCH1 Proteine)-dependent differentiation program.
Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.
PDK1 was highly expressed in synovia of collagen-induced-arthritis mice compared to control. The expressions of PDK1, p-PDK1, RSK2 (zeige RPS6KA3 Proteine) and p-RSK2 (zeige RPS6KA3 Proteine) were all up-regulated in CIA (zeige NCOA5 Proteine) compared with normal. This indicated that PDK1/RSK2 (zeige RPS6KA3 Proteine) may participate in inflammatory progress of RA.
PDK1 is required for Ca(2 (zeige CA2 Proteine)+)-dependent platelet activation on stimulation of collagen receptor (zeige ITGA2 Proteine) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.
In conclusion, we have identified that ARL15 acts as an insulin (zeige INS Proteine)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (zeige IRS1 Proteine)/PDPK1/AKT (zeige AKT1 Proteine) insulin (zeige INS Proteine) pathway by interacting with its GAP ASAP2 (zeige ASAP2 Proteine) and activating PDPK1. This research may provide new insights into GTPase (zeige RACGAP1 Proteine)-mediated insulin (zeige INS Proteine) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (zeige INS Proteine) sensitizati
Only when suboptimal doses of Akt (zeige AKT1 Proteine)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (zeige NOTCH1 Proteine) inhibition was seen. We conclude that the Akt (zeige AKT1 Proteine) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (zeige AKT1 Proteine) signaling.
Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (zeige NFKB1 Proteine).
PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.
The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.
The authors show that loss of frataxin homolog (fh (zeige FXN Proteine)) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2 (zeige MYEF2 Proteine)).
PDK1 is also a presynaptic protein, though it is distributed more broadly.
dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (zeige CDK7 Proteine) 1, dPDK1
at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (zeige PIK3C3 Proteine) (PI3K)
Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
PDK1 (zeige PDK1 Proteine) undergoes autophosphorylation at several sites; mutation of Ser (zeige SIGLEC1 Proteine)-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp (zeige ASIP Proteine)-167, Thr (zeige TRH Proteine)-176, & Thr (zeige TRH Proteine)-211
PDK1 (zeige PDK1 Proteine) is a potent enhancer of PID (zeige MTA2 Proteine) activity.
specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.
3-phosphoinositide-dependent protein kinase 1
, 3-phosphoinositide dependent protein kinase-1
, pkB kinase
, protein kinase B kinase
, PkB kinase like gene 1
, Pkb kinase
, ATP synthase c subunit
, ATP synthase lipid-binding protein, mitochondrial
, ATP synthase proteolipid P2
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
, ATPase protein 9
, ATPase subunit C
, mitochondrial ATP synthase, subunit C (subunit 9)
, phosphoinositide dependent kinase 1
, phosphoinositide-dependent kinase 1
, protein kinase 61C
, serine/threonine protein kinase
, pyruvate dehydrogenase kinase 1
, pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial