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Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
cyclin D1 was downregulated, whereas Bcell lymphoma 2associated agonist of cell death (BAD) was upregulated following RAC1 knockdown in colon cancer cells.
Studied effects of Taxillus yadoriki and Neolitsea sericea extracts on cell proliferation of cancer cells through cyclin D1 proteasomal degradation.
Findings indicate the substrate specificity of the F-box protein FBXO31 (zeige FBXO5 Proteine) and the mechanism of FBXO31 (zeige FBXO5 Proteine)-regulated cyclin D1 protein turnover.
The authors report a previously unknown long noncoding RNA which, together with CNBP (zeige CNBP Proteine), is involved in the fine-tuned regulation of CCND1 mRNA stability, without which CCND1 exhibits, at most, partial expression.
According to immunohistochemistry and immunoblot analysis, the expression levels of cyclin D1, cyclin E (zeige CCNE1 Proteine), pRb (zeige RB1 Proteine), and Ki67 (zeige MKI67 Proteine) in psoriasis lesions decreased after treatment and were similar with those in the normal group
Further study revealed AP000439.3 can regulate expression of CCND1 through enhancing estrogen receptor (zeige ESR1 Proteine) induction of CCND1. This finding revealed lncRNAs may serve as important effectors of ER in regulation of gene expression and cell phenotype in breast cancer
miR (zeige MLXIP Proteine)-720 acted as a tumour suppressor in pancreatic cancer by directly targeting CCND1.
Results identified NKX2-1 (zeige NKX2-1 Proteine)-binding motifs in the cyclin D1 promoter and indicate that NKX2-1 (zeige NKX2-1 Proteine) directly and positively regulates transcription of cyclin D1 in lung adenocarcinoma.
Results suggest that dysregulation and activation of the cell cycle proteins CDK4 (zeige CDK4 Proteine)/CDK6 (zeige CDK6 Proteine)-CCND1-phospho-RB1 (zeige RB1 Proteine) axis is associated with higher proliferative index in neuroendocrine tumors (NETs).
Results indicated that miR (zeige MLXIP Proteine)-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting cyclin D1 (CCND1) and ETS (zeige ETS1 Proteine) proto-oncogene (zeige RAB1A Proteine) 1 (ETS1 (zeige ETS1 Proteine)) expression.
Since miR (zeige MLXIP Proteine)-290 cluster miRNAs are the most dominant stem-cell-specific miRNAs, our results revealed an important cause for the absence of Cyclin D1 in mouse embryonic stem cells
beta-catenin (zeige CTNNB1 Proteine) and p65 (zeige NFkBP65 Proteine) are activated in separate cellular compartments during liver regeneration, with p65 (zeige NFkBP65 Proteine) activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin (zeige CTNNB1 Proteine), cyclin D1 expression, and subsequent proliferation
Ablation of periostin (zeige POSTN Proteine) suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin (zeige POSTN Proteine) is essential for myocardial regeneration.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF (zeige CSF1R Proteine)/c-Fms (zeige CSF1R Proteine)-mediated downstream signaling pathways like activation of ERK (zeige EPHB2 Proteine) and Akt (zeige AKT1 Proteine) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (zeige CTNNB1 Proteine)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (zeige PAX5 Proteine) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), Klf4 (zeige KLF4 Proteine), and c-Myc (zeige MYC Proteine) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (zeige PLCG1 Proteine) controls osteoclast numbers via a CSF-1 (zeige CSF1 Proteine)-dependent DAG/beta-catenin (zeige CTNNB1 Proteine)/cyclinD1 pathway.
Methylparabens exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a (zeige SMC1A Proteine) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (zeige MEIS1 Proteine) regulating cyclin D1 and c-myc (zeige MYC Proteine) transcription in the embryonic eye.
Results suggest that the TCF (zeige HNF4A Proteine)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (zeige CDK2 Proteine) and CDK4 (zeige CDK4 Proteine) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (zeige MAPK3 Proteine) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1