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Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
our data demonstrated for the first time that inhibition of RAD51 (zeige RAD51 Proteine) suppressed the cervical cancer cell proliferation and the growth of cervical cancer xenografts by attenuating cell cycle transition, which could be a functional link between RAD51 (zeige RAD51 Proteine) and cyclin D1 and p21 (zeige CDKN1A Proteine)
REVIEW: addresses the implication of SOX11 (zeige SOX11 Proteine) overexpression and frequent genetic lesions, cooperating with cyclin D1 underlying the pathogenesis of mantle cell lymphoma
A significant association between CCND1 c.870G>A polymorphism and breast cancer risk.
The study demonstrated that UCA1 is a critical regulator involved in gastric cancer cells proliferation and cell cycle progression by promoting cyclin D1 expression.
These findings uncover a new mechanism that is critical for the regulation of CCND1 protein levels, and is directly relevant to primary ibrutinib resistance in MCL (zeige FH Proteine).
Sphk1 (zeige SPHK1 Proteine) induced NF-kappaB (zeige NFKB1 Proteine)-p65 (zeige GORASP1 Proteine) activation, increased expression of cyclin D1, shortened the cell division cycle, and thus promoted proliferation of breast epithelial cells.
TMPRSS4 (zeige TMPRSS4 Proteine) modulates both invasion and proliferation via Slug and cyclin D1, which is a previously unrecognized pathway that may regulate metastasis and cancer progression
miR (zeige MLXIP Proteine)-202 plays an important role in regulating cell proliferation, migration and invasion of cervical cancer by directly targeting cyclin D1.
This study demonstrated that IB-MECA induces G1 phase cell cycle arrest through Cyclin D1/CDK4 (zeige CDK4 Proteine)-mediated pathway in ovarian cancer cells.
Cyclin D1 is unsuitable for minimal residual disease monitoring in bone marrow of patients with mantle cell lymphoma.
Ablation of periostin (zeige POSTN Proteine) suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin (zeige POSTN Proteine) is essential for myocardial regeneration.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF (zeige CSF1R Proteine)/c-Fms (zeige CSF1R Proteine)-mediated downstream signaling pathways like activation of ERK (zeige EPHB2 Proteine) and Akt (zeige AKT1 Proteine) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (zeige CTNNB1 Proteine)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (zeige PAX5 Proteine) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), Klf4 (zeige KLF4 Proteine), and c-Myc (zeige MYC Proteine) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (zeige PLCG1 Proteine) controls osteoclast numbers via a CSF-1 (zeige CSF1 Proteine)-dependent DAG/beta-catenin (zeige CTNNB1 Proteine)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (zeige MYC Proteine), Cyc (zeige CYCS Proteine)-D1 and TERT (zeige TERT Proteine), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (zeige DND1 Proteine) susceptible mice without being necessary for normal germ cell or testis development.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a (zeige SMC1A Proteine) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (zeige MEIS1 Proteine) regulating cyclin D1 and c-myc (zeige MYC Proteine) transcription in the embryonic eye.
Results suggest that the TCF (zeige HNF4A Proteine)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (zeige CDK2 Proteine) and CDK4 (zeige CDK4 Proteine) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (zeige MAPK3 Proteine) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1