anti-ATG13 (ATG13) Antikörper

Human Autophagy Related 13 (ATG13) Interaktionspartner

1. these results demonstrate the effective anti-autophagic of NRAGE (zeige MAGED1 Antikörper) in non-small-cell lung cancer cells through AMPK (zeige PRKAA1 Antikörper)/Ulk1 (zeige ULK1 Antikörper)/Atg13 autophagy signaling pathways. Therefore, NRAGE (zeige MAGED1 Antikörper) could be used as a potential therapeutic target for lung cancer.

2. These results show that the SiMoA technology can detect quantitatively low levels of endogenous biomarkers with the ability to detect the loss of pSer(318)-Atg13 upon ULK1 (zeige ULK1 Antikörper) inhibition.

3. Structure of the human Atg13-Atg101 (zeige C12orf44 Antikörper) HORMA heterodimer in the ULK1 (zeige ULK1 Antikörper) complex that controls autophagy has been described.

4. Specific affinity of the LC3 (zeige MAP1LC3A Antikörper) isoforms to the Atg13 LC3 (zeige MAP1LC3A Antikörper)-interacting region is required for proper autophagosome formation.

5. In response to DNA damage, ULK1 (zeige ULK1 Antikörper) and ULK2 (zeige ULK2 Antikörper) are upregulated by p53 (zeige TP53 Antikörper). The upregulation of ULK1 (zeige ULK1 Antikörper) (ULK2 (zeige ULK2 Antikörper))/ATG13 complex by p53 (zeige TP53 Antikörper) is necessary for the sustained autophagy activity induced by DNA damage.

6. The gene product is the functional homologue of yeast Atg13, and required for autophagy in mammalian cells.

7. mTORC1 suppresses autophagy through direct regulation of the approximately 3-MDa ULK1 (zeige ULK1 Antikörper)-Atg13-FIP200 (zeige RB1CC1 Antikörper) complex.

8. The ULK-Atg13-FIP200 (zeige RB1CC1 Antikörper) complexes are direct targets of mTOR (zeige FRAP1 Antikörper) and important regulators of autophagy in response to mTOR (zeige FRAP1 Antikörper) signaling.

9. ATG13 and ULK1 (zeige ULK1 Antikörper) are phosphorylated by the mTOR (zeige FRAP1 Antikörper) pathway in a nutrient starvation-regulated manner, indicating that the ULK1 (zeige ULK1 Antikörper).ATG13.FIP200 (zeige RB1CC1 Antikörper) complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis.

10. The identification of the novel protein, Atg101 (zeige C12orf44 Antikörper), and the validation of Atg13 and Atg101 (zeige C12orf44 Antikörper) as ULK1 (zeige ULK1 Antikörper)-interacting proteins, suggests an Atg1 (zeige ULK1 Antikörper) complex is involved in the induction of macroautophagy in mammalian cells.

Mouse (Murine) Autophagy Related 13 (ATG13) Interaktionspartner

1. ATG7 (zeige ATG7 Antikörper), but not ATG13 or ULK1 (zeige ULK1 Antikörper) has a role in functional autophagy in glioblastoma development

2. ATG13 phosphorylation plays a crucial role in autophagy regulation.

3. autophagy can be executed by mechanisms that are dependent or independent of the ULK1 (zeige ULK1 Antikörper)/2-ATG13 interaction.

4. Atg13-deficient embryos show growth retardation and myocardial growth defects.