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Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN361978
Kim, Lee, Kim, Bahk: A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. in Proteomics 2008
Show all 21 Pubmed References
Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN362584
Bahk, Cho, Kim: A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts. in Biochemical and biophysical research communications 2008
Show all 15 Pubmed References
Human Polyclonal AKT Primary Antibody für CyTOF, FACS - ABIN4900619
Wang, Yue, Kim, Fu, Khuri, Sun: Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. in Cancer research 2008
Show all 12 Pubmed References
Human Monoclonal AKT Primary Antibody für IHC, IHC (p) - ABIN252685
Luty, Rodeberg, Parness, Vyas: Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 8 Pubmed References
Human Monoclonal AKT Primary Antibody für ICS - ABIN1177030
Prinz, Mendler, Masouris, Durner, Oberneder, Noessner: High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 7 Pubmed References
Human Polyclonal AKT Primary Antibody für IF, IHC - ABIN361980
Tremblay, Krebs, Dombrowski, Brehm, Bernroider, Roth, Nowotny, Waldhäusl, Marette, Roden: Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. in Diabetes 2005
Show all 10 Pubmed References
Human Polyclonal AKT Primary Antibody für IP, WB - ABIN223018
Artwohl, Muth, Kosulin, de Martin, Hölzenbein, Rainer, Freudenthaler, Huttary, Schmetterer, Waldhäusl, Baumgartner-Parzer: R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. in American journal of physiology. Endocrinology and metabolism 2007
Show all 6 Pubmed References
Human Monoclonal AKT Primary Antibody für WB - ABIN4279016
Nair, Shishodia, Ahn, Kunnumakkara, Sethi, Aggarwal: Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 6 Pubmed References
Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN362586
Xu, Stippec, Lazrak, Huang, Cobb: WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. in The Journal of biological chemistry 2005
Show all 9 Pubmed References
Dog (Canine) Monoclonal AKT Primary Antibody für IF, IP - ABIN968206
Cross, Alessi, Cohen, Andjelkovich, Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. in Nature 1996
Show all 5 Pubmed References
IL-10 (zeige IL10 Antikörper) stimulation activated the JAK (zeige JAK3 Antikörper)/Stat-3 (zeige STAT3 Antikörper) and PI3K (zeige PIK3CA Antikörper)/Akt signaling pathways. Moreover, IL-10 (zeige IL10 Antikörper) treatment increased translocation of p65 NF-kappaB (zeige NFkBP65 Antikörper) into the nuclear compartment, and up-regulated expression of the pro-survival proteins Bcl-2 (zeige BCL2 Antikörper) and Bcl-xL (zeige BCL2L1 Antikörper).
AKT1 and AKT2 (zeige AKT2 Antikörper) isoforms have opposing roles in smooth muscle cell proliferation, migration, differentiation, and rapamycin response in vitro and in vascular injury in vivo.
our results revealed that As2S2 induced G2/M phase arrest, apoptosis, and autophagy via activing ROS (zeige ROS1 Antikörper)/JNK (zeige MAPK8 Antikörper) and blocking Akt/mTOR (zeige FRAP1 Antikörper) signaling pathway in human osteosarcoma cells. Arsenic sulfide (zeige SQRDL Antikörper) may be a potential clinical antitumor drugs targeting osteosarcoma.
Overexpression of KAT6A (zeige MYST3 Antikörper) or TRIM24 (zeige TRIM24 Antikörper) promoted PIK3CA (zeige PIK3CA Antikörper) expression, AKT phosphorylation, and cell proliferation.
Report frequency of genetic variation in Akt1 and discuss link to cancer.
Data show that cancer-associated fibroblasts (CAFs (zeige TBX1 Antikörper))-derived hepatocyte growth factor (HGF (zeige HGF Antikörper)) or recombinant HGF (zeige HGF Antikörper) activated c-Met/phosphoinositide 3-kinase (PI3K (zeige PIK3CA Antikörper))/Akt and glucose-regulated protein 78 (GRP78 (zeige HSPA5 Antikörper)) signalling pathways in ovarian cancer cells.
Receptor tyrosine kinase (zeige RET Antikörper) activation of RhoA (zeige RHOA Antikörper) is mediated by AKT phosphorylation of DLC1 (zeige DYNLL1 Antikörper).
ablation of Glut1 (zeige SLC2A1 Antikörper) attenuated apoptosis and increased drug resistance via upregulation of p-Akt/p-GSK-3beta (zeige GSK3b Antikörper) (Ser9)/beta-catenin (zeige CTNNB1 Antikörper)/survivin (zeige BIRC5 Antikörper).
frequent upregulation of MIF (zeige AMH Antikörper) is implicated in the development and progression ofesophageal squamous cell carcinoma (ESCC).
T-type channel signaling is redirected towards the activation of the kinase Akt1, leading to increased expression of the anti-apoptotic protein survivin (zeige BIRC5 Antikörper), and a decrease in the pro-apoptotic mediator FoxO3A (zeige FOXO3 Antikörper). Finally, in iPAH cells, Akt1 is no longer able to regulate caspase 9 (zeige CASP9 Antikörper) activation, whereas T-type channel overexpression reverses PP2A (zeige PPP2R4 Antikörper) defect in iPAH cells but reinforces the deleterious effects of Akt1 activation
L. donovani triggered AKT activation to regulate GSK-3beta (zeige GSK3b Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)/FOXO-1 (zeige FOXO1 Antikörper) axis.
Collectively, these findings highlight that a single IRR (zeige INSRR Antikörper) dose is sufficient to disrupt the regulation of Akt signaling in atrophying skeletal muscle.
we show that simultaneous inhibition of mTOR (zeige FRAP1 Antikörper) signaling to both S6K1 (zeige RPS6KB1 Antikörper) and 4E-BP1 (zeige EIF4EBP1 Antikörper) is sufficient to reduce AKT-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
Data show that tumors lacking PSMA (zeige FOLH1 Antikörper) had less than half the abundance of type 1 insulin (zeige INS Antikörper)-like growth factor receptor (zeige RYK Antikörper) (IGF-1R (zeige IGF1R Antikörper)), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK (zeige MAPK1 Antikörper)-ERK1/2 (zeige MAPK1/3 Antikörper) signaling.
EGCG significantly ameliorated insulin (zeige INS Antikörper) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1 (zeige IRS1 Antikörper))/AKT and ERK (zeige EPHB2 Antikörper)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (zeige BDNF Antikörper)) signaling pathways.
cells stimulated with BMP-2 (zeige BMP2 Antikörper) in the presence of FBS (zeige FBS Antikörper) require the phosphorylation of Akt at Ser473 and the dephosphorylation of Akt at Thr308 to increase the osteoblast differentiation with alkaline phosphatase activity similar to that of BMP-9 (zeige GDF2 Antikörper) plus FBS (zeige FBS Antikörper).
Data suggest that activity of neuronal enzymes Akt1 and p38Mapk (zeige MAPK14 Antikörper) can be modulated by dietary factors; here, subchronic administration of ascorbic acid (a common antioxidant, antidepressant dietary supplement) at 1 mg/kg increases Akt1 phosphorylation in cerebral cortex of mice and decreases hippocampal p38Mapk (zeige MAPK14 Antikörper) phosphorylation. (Akt1 = thymoma viral proto-oncogene 1; p38Mapk (zeige MAPK14 Antikörper) = p38 MAP kinase (zeige MAPK14 Antikörper))
Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta (zeige GSK3b Antikörper)(Ser9) and Akt(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta (zeige GSK3b Antikörper) signaling axis at cilia in SHH (zeige SHH Antikörper)-dependent medulloblastoma that is regulated by INPP5E (zeige INPP5E Antikörper) to maintain tumor cell cilia, promote SHH (zeige SHH Antikörper) signaling and thereby medulloblastoma progression.
The metabolic defects of cycG (zeige CCNG1 Antikörper) mutant animals are abrogated by a concomitant loss of Wdb, CycG (zeige CCNG1 Antikörper) presumably influences Akt1 activity at the PP2A (zeige PPP2R2B Antikörper) nexus; Well rounded (Wrd), another B' subunit of PP2A (zeige PPP2R2B Antikörper) in Drosophila, binds CycG (zeige CCNG1 Antikörper) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (zeige CCNG1 Antikörper) mutants.
Our findings demonstrated that lovastatin restored LRRK2 (zeige LRRK2 Antikörper)-G2019S neurite degeneration by augmenting Akt/NRF2 (zeige NFE2L2 Antikörper) pathway and inhibiting downstream GSK3b (zeige GSK3b Antikörper) activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (zeige LRRK2 Antikörper)-G2019S parkinsonism.
These findings revise the existing spermiation model in Drosophila and suggest that somatic cells can actively oppose mechanical cell invasion attempts using calibrated F-actin dynamics in situ
subtle manipulation of foxo (zeige FOXO Antikörper) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (zeige GRIN1 Antikörper) localization, and postsynaptic membrane elaboration
Tsc2 (zeige TSC2 Antikörper) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (zeige TSC2 Antikörper) mutants, leading to the hypothesis that Tsc2 (zeige TSC2 Antikörper) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
This study showed that beta-actin (zeige ACTB Antikörper), L32 (zeige RPL32 Antikörper) ribosomal protein, and ATP5B (zeige ATP5B Antikörper) proteins were the most stabily expressed genes in cryopreserved horse semen.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 Antikörper) accumulation and subsequent ovarian E2 production.
Caveolin-1 (zeige CAV1 Antikörper) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (zeige TGM2 Antikörper) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (zeige GSK3b Antikörper), and NF-kappaB (zeige NFKB1 Antikörper).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 Antikörper), reactive oxygen species, and PI3-kinase (zeige PIK3CA Antikörper) in stimulated NO release.
PI3K/Akt and p53 (zeige TP53 Antikörper) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR (zeige FRAP1 Antikörper), p70S6K (zeige RPS6KB1 Antikörper), and ERK1/2 (zeige MAPK1/3 Antikörper).
Gab1 (zeige GAB1 Antikörper) tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (zeige NOS3 Antikörper) activation in endothelial cells
Losartan metabolite stimulates eNOS (zeige NOS3 Antikörper) phosphorylation and suppresses tumor necrosis factor alpha (zeige TNF Antikörper)-induced endothelial cell apoptosis by activating AKT1.
These findings highlight novel and essential roles of PFKFB4 (zeige PFKFB4 Antikörper) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
SCF (zeige KITLG Antikörper) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (zeige FRAP1 Antikörper)-FOXO1 (zeige FOXO1 Antikörper) signaling and suppressing the activation of TLR4 (zeige TLR4 Antikörper) and/or NOD2 (zeige NOD2 Antikörper) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (zeige LRP2 Antikörper) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB Antikörper); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (zeige FNTA Antikörper), which further represses the activity of K(+) channel (zeige KCNC4 Antikörper) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (zeige CBL Antikörper)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (zeige CA2 Antikörper)+)-dependent manner, connecting the Ca(2 (zeige CA2 Antikörper)+) signal to K(+) uptake through activation of a K(+) channel (zeige KCNC4 Antikörper).
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (zeige TP53 Antikörper).
Modulation of pptr-1 affects insulin (zeige INS Antikörper)/IGF-1 (zeige IGF1 Antikörper) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (zeige TRH Antikörper) 350.
Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (zeige RPS6KB1 Antikörper) (Thr389) and 4E-BP1 (zeige EIF4EBP1 Antikörper) (Thr37/46) in goat fetal fibroblasts.
findings suggested that the expressions of the cardiac CACNA1C (zeige CACNA1C Antikörper) were under the CLOCK-BMAL1 (zeige ARNTL Antikörper) regulation, probably through the PI3K-Akt signal pathway
Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, actin, cytoplasmic 1
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, gamma non-muscle actin
, beta actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1