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anti-Human AKT Antikörper:
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Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN361978
Kim, Lee, Kim, Bahk: A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. in Proteomics 2008
Show all 21 Pubmed References
Human Polyclonal AKT Primary Antibody für ELISA, ICC - ABIN6259867
He, Cao, Liu, Li, Xu, Liu, Shi: Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway. in Experimental cell research 2016
Show all 19 Pubmed References
Human Polyclonal AKT Primary Antibody für ELISA, ICC - ABIN6255359
Yao, Jiang, Zhang, Liu, Du, Feng: Chrysin alleviates allergic inflammation and airway remodeling in a murine model of chronic asthma. in International immunopharmacology 2016
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Human Polyclonal AKT Primary Antibody für CyTOF, FACS - ABIN4900619
Wang, Yue, Kim, Fu, Khuri, Sun: Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. in Cancer research 2008
Show all 19 Pubmed References
Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN362584
Bahk, Cho, Kim: A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts. in Biochemical and biophysical research communications 2008
Show all 15 Pubmed References
Mouse (Murine) Polyclonal AKT Primary Antibody für WB - ABIN4886448
Qin, Niu, Wang, Xu, Qiao, Gu: Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway. in Cardiovascular diabetology 2013
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Chicken Monoclonal AKT Primary Antibody für WB - ABIN3043108
Wang, Li, Lu, Bao, Zhao: Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy. in Journal of diabetes and its complications 2012
Show all 11 Pubmed References
Human Polyclonal AKT Primary Antibody für WB - ABIN3044493
Wang, Li, Lu, Zhao, Xu: Taurine attenuates oxidative stress and alleviates cardiac failure in type I diabetic rats. in Croatian medical journal 2013
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Human Monoclonal AKT Primary Antibody für IHC, IHC (p) - ABIN252685
Luty, Rodeberg, Parness, Vyas: Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Monoclonal AKT Primary Antibody für ICS - ABIN1177030
Prinz, Mendler, Masouris, Durner, Oberneder, Noessner: High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention. in Journal of immunology (Baltimore, Md. : 1950) 2012
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Circ-CFH (zeige CFH Antikörper) promotes glioma progression by sponging miR (zeige MLXIP Antikörper)-149 and regulating the AKT1 signaling pathway.
High AKT1 expression is associated with metastasis via epithelialmesenchymal transition carcinoma in colorectal cancer.
High AKT1 expression is associated with tumor-node-metastasis in nonsmall cell lung cancer.
High expression of AKT1 is associated with drug resistance and proliferation of breast cancer.
Germline variants in AKT1 gene are associated with prostate cancer.
High AKT1 expression is associated with cisplatinresistant oral cancer.
that Akt1 was a novel target for miR (zeige MLXIP Antikörper)-637, and its knockdown also induced cell growth inhibition and apoptosis in pancreatic ductal adenocarcinoma cells
High AKT1 expression is associated with periodontitis.
High AKT1 expression is associated with angiogenesis of esophageal squamous cell carcinoma.
High AKT1 expression is associated with Pancreatic Ductal Adenocarcinoma Metastasis.
M-CSF (zeige CSF1R Antikörper)-evoked ERK1/2 activation was decreased, whereas AKT activation was enhanced in SHP2 (zeige PTPN11 Antikörper)-deficient BMMs. ERK1/2, via its downstream target RSK2 (zeige RPS6KA3 Antikörper), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (zeige CSF1R Antikörper) receptor at Tyr721 and, consequently, its binding to p85 (zeige ECM1 Antikörper) subunit of PI3K and PI3K activation.
Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR (zeige ADH5 Antikörper)(+/+)ApoE (zeige APOE Antikörper)(-/-) littermate controls, GSNOR (zeige ADH5 Antikörper)(-/-)ApoE (zeige APOE Antikörper)(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis.
the present study suggested that Pulsed electromagnetic fields (PEMFs) reduced osteoclast formation from RAW264.7 macrophages via inhibition of the Akt/mTOR (zeige FRAP1 Antikörper) signaling pathway. These findings provided novel insight into the mechanisms through which PEMFs suppress osteoclast differentiation.
findings uncover a new function of p53 (zeige TP53 Antikörper) in the regulation of Akt signaling and reveal how p53 (zeige TP53 Antikörper), ASS1 (zeige ASS1 Antikörper), and Akt are interrelated to each other.
Here, we describe a role for PI3K/AKT in the regulation of TRF1 (zeige TERF1 Antikörper), an essential component of the shelterin complex. PI3K and AKT chemical inhibitors reduce TRF1 (zeige TERF1 Antikörper) telomeric foci and lead to increased telomeric DNA damage and fragility. TRF1 (zeige TERF1 Antikörper) is phosphorylated by AKT regulating TRF1 (zeige TERF1 Antikörper) protein stability and TRF1 (zeige TERF1 Antikörper) binding to telomeric DNA in vitro and are important for in vivo TRF1 (zeige TERF1 Antikörper) telomere location and cell viability.
High AKT1 expression is associated with cardiac hypertrophy.
CTRP1 protected against Dox-induced cardiotoxicity via activation of AKT
Noise exposure led to enhanced JNK (zeige MAPK8 Antikörper) phosphorylation and IRS1 (zeige IRS1 Antikörper) serine phosphorylation as well as reduced Akt phosphorylation in skeletal muscles in response to exogenous insulin (zeige INS Antikörper) stimulation.
WT PDCD5 (zeige PDCD5 Antikörper) competitively inhibited interaction between histone deacetylase 3 (HDAC3 (zeige HDAC3 Antikörper)) and AKT, but PDCD5 (zeige PDCD5 Antikörper)(L6R), an HDAC3 (zeige HDAC3 Antikörper)-binding-deficient mutant, did not. Knockdown of PDCD5 (zeige PDCD5 Antikörper) accelerated HDAC3 (zeige HDAC3 Antikörper)-AKT interaction, AKT and eNOS (zeige NOS3 Antikörper) phosphorylation, and nitric oxide (NO) production
both NAD and NADH significantly increased the intracellular ATP levels of BV2 (zeige DNAH9 Antikörper) microglia, which were attenuated by SIRT2 (zeige SIRT2 Antikörper) siRNA, the SIRT2 (zeige SIRT2 Antikörper) inhibitor AGK2 (zeige GUK1 Antikörper), and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002. Results suggested that SIRT2 (zeige SIRT2 Antikörper) mediates the NAD-induced and NADH-induced increase in Akt phosphorylation in BV2 (zeige DNAH9 Antikörper) microglia.
The metabolic defects of cycG (zeige CCNG1 Antikörper) mutant animals are abrogated by a concomitant loss of Wdb, CycG (zeige CCNG1 Antikörper) presumably influences Akt1 activity at the PP2A (zeige PPP2R2B Antikörper) nexus; Well rounded (Wrd), another B' subunit of PP2A (zeige PPP2R2B Antikörper) in Drosophila, binds CycG (zeige CCNG1 Antikörper) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (zeige CCNG1 Antikörper) mutants.
Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism.
subtle manipulation of foxo (zeige FOXO Antikörper) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (zeige GRIN1 Antikörper) localization, and postsynaptic membrane elaboration
Tsc2 (zeige TSC2 Antikörper) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (zeige TSC2 Antikörper) mutants, leading to the hypothesis that Tsc2 (zeige TSC2 Antikörper) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Thus, activation of STAT3 (zeige STAT3 Antikörper) and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 Antikörper) accumulation and subsequent ovarian E2 production.
Caveolin-1 (zeige CAV1 Antikörper) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (zeige TGM2 Antikörper) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (zeige NFKB1 Antikörper).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 Antikörper), reactive oxygen species, and PI3-kinase (zeige PIK3CA Antikörper) in stimulated NO release.
PI3K/Akt and p53 (zeige TP53 Antikörper) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (zeige NOS3 Antikörper) activation in endothelial cells
These findings highlight novel and essential roles of PFKFB4 (zeige PFKFB4 Antikörper) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
Studied the effects of microRNA-27a on myogenin (zeige MYOG Antikörper) expression and the Akt/FoxO1 (zeige FOXO1 Antikörper) signal pathway during porcine myoblast differentiation. Overexpression of miR (zeige MYLIP Antikörper)-27a suppressed myogenin (zeige MYOG Antikörper) expression during porcine myoblast differentiation, whereas inhibition of miR (zeige MYLIP Antikörper)-27a promoted the mRNA and protein expression levels of myogenin (zeige MYOG Antikörper); overexpression of miR (zeige MYLIP Antikörper)-27a decreased the level of P-Akt/Akt and increased the protein level of FoxO1 (zeige FOXO1 Antikörper).
SCF (zeige KITLG Antikörper) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (zeige FRAP1 Antikörper)-FOXO1 (zeige FOXO1 Antikörper) signaling and suppressing the activation of TLR4 (zeige TLR4 Antikörper) and/or NOD2 (zeige NOD2 Antikörper) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK (zeige PTK2 Antikörper)-PI3K-AKT-Rac1 (zeige RAC1 Antikörper) signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (zeige LRP2 Antikörper) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB Antikörper); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (zeige FNTA Antikörper), which further represses the activity of K(+) channel (zeige KCNC4 Antikörper) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (zeige CBL Antikörper)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (zeige CA2 Antikörper)+)-dependent manner, connecting the Ca(2 (zeige CA2 Antikörper)+) signal to K(+) uptake through activation of a K(+) channel (zeige KCNC4 Antikörper).
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (zeige TP53 Antikörper).
Modulation of pptr-1 affects insulin (zeige INS Antikörper)/IGF-1 (zeige IGF1 Antikörper) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (zeige TRH Antikörper) 350.
Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (zeige RPS6KB1 Antikörper) (Thr389) and 4E-BP1 (zeige EIF4EBP1 Antikörper) (Thr37/46) in goat fetal fibroblasts.
findings suggested that the expressions of the cardiac CACNA1C (zeige CACNA1C Antikörper) were under the CLOCK-BMAL1 (zeige ARNTL Antikörper) regulation, probably through the PI3K-Akt signal pathway
This study has identified Akt as a novel intracellular pathway required for neural crest differentiation.
Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, actin, cytoplasmic 1
, gamma non-muscle actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1