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anti-Mouse (Murine) PER1 Antikörper:
anti-Human PER1 Antikörper:
anti-Rat (Rattus) PER1 Antikörper:
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Human Polyclonal PER1 Primary Antibody für WB - ABIN1536671
Hwang-Verslues, Chang, Jeng, Kuo, Chiang, Chang, Hsieh, Su, Lin, Abbondante, Yang, Hsu, Yu, Chang, Shew, Lee, Lee: Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. in Proceedings of the National Academy of Sciences of the United States of America 2013
Atxn2 (zeige ATXN2 Antikörper)(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 and PER2 (zeige PER2 Antikörper) IR in the SCN (zeige SRI Antikörper) did not differ between genotypes.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
beta-amyloid protein (31-35) altered the expression of the Per1 and Per2 in the suprachiasmatic nucleus, hippocampus and heart. These findings provide experimental evidence for circadian rhythm disturbances in patients with Alzheimer's disease.
In vivo knockdown of Rfk (zeige RFK Antikörper), Riboflavin (vitamin B2) kinase essential for FAD (zeige FANCD2 Antikörper) synthesis, altered the expression rhythms of CRY1 (zeige CRY1 Antikörper), CRY2 (zeige CRY2 Antikörper), and PER1
these data support an important role for the circadian clock protein (zeige ARNTL Antikörper) PER1 in the modulation of blood pressure in a high salt/mineralocorticoid model of hypertension
Per1 knockdown leads to JNK (zeige MAPK8 Antikörper) phosphorylation, CCL2 (zeige CCL2 Antikörper) production and allodynia.
Deletion of Per1 alleviated the inhibitory effect of PPAR-gamma (zeige PPARG Antikörper) on CC chemokine receptor 2 (zeige CCRL2 Antikörper) expression, resulting in enhanced macrophage recruitment into the liver.
Rate-limiting mitochondrial enzymes that process lipids and carbohydrates accumulate in a diurnal manner and are dependent on the clock proteins PER1/2. Diurnal regulation of mitochondrial respiration was blunted in PER1/2 knockout mice.
that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 and Per2 (zeige PER2 Antikörper) genes under abnormal light-dark conditions
measured gene expression of Fos, Per1 and Sgk1 (zeige SGK1 Antikörper) 45 min after exposure to brief cold swim stress in male and female mice; stress induced a stronger increase in Fos and Per1 expression in females than males
Low PER1 expression is associated with oral squamous cell carcinoma.
Low Per1 gene expression is associated with colorectal liver metastases.
The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy. PER1 c.2884C > G polymorphism may be associated with risk of non-response to HT in postmenopausal Korean women.
ARNTL (zeige ARNTL Antikörper) and PER1 were associated with PD.
Collectively, these data show that KPNB1 (zeige KPNB1 Antikörper) is required for timely nuclear import of PER/CRY (zeige CRY2 Antikörper) in the negative feedback regulation of the circadian clock.
when overexpressed, c-MYC (zeige MYC Antikörper) is able to repress Per1 transactivation by BMAL1 (zeige ARNTL Antikörper)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (zeige MYC Antikörper) was detected in BMAL1 (zeige ARNTL Antikörper) protein complexes
Period 1 and estrogen receptor-beta (zeige ESR2 Antikörper) are downregulated in Chinese colon cancers.
Data demonstrate a role for Per1 in the transcriptional regulation of NHE3 (zeige SLC9A3 Antikörper) and SGLT1 (zeige SLC5A1 Antikörper) in the kidney.
In adipose tissue, acute sleep deprivation vs sleep increased methylation in two promoter-interacting enhancer regions of PER1
In patients with non-small cell lung cancer, loss of Per1 was correlated with poor differentiation, tumor status, high p-TNM stage and lymph node metastasis. Patients with lower expression of Per1, Per2 and Per3 had a shorter survival time.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene\; however, these variants have not been fully described.
, period homolog 1
, circadian clock protein PERIOD 1
, circadian pacemaker protein Rigui
, period circadian protein homolog 1
, Period, drosophila, homolog of
, circadian pacemaker protein RIGUI