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Phosphatidylinositol Binding clathrin Assembly Protein Proteine

(Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10\;11)(p13\;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].

5 Treffer

PICALM Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Pubmed 1 reference
Produktnummer ABIN1315001
 
PICALM Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Pubmed 1 reference
Produktnummer ABIN2728884
 
PICALM Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % WB, SDS, Imm, PC
Produktnummer ABIN7408408
 
PICALM Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant WB, SDS
Produktnummer ABIN6125382
 
PICALM Spezies: Ratte Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN7585533
 
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • ELISA
    • SDS-PAGE (SDS)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Standard (STD)
  • Reaktivität
    • Human
    • Rat
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Wheat germ
    • Yeast
  • Bindungsspezifität
    • AA 1-610
    • AA 19-285
    • AA 2-640
    • Transcript Variant 1
  • Konjugat
    • His tag
    • GST tag
    • Myc-DYKDDDDK Tag
    • Unkonjugiert
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Hersteller
    • antibodies-online
    • Abbexa
    • CUSABIO
    • OriGene

Aktuelle Publikationen für unsere Phosphatidylinositol Binding clathrin Assembly Protein Proteine

Zhao, Sagare, Ma, Halliday, Kong, Kisler, Winkler, Ramanathan, Kanekiyo, Bu, Owens, Rege, Si, Ahuja, Zhu, Miller, Schneider, Maeda, Maeda, Sugawara, Ichida, Zlokovic: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).

Baig, Joseph, Tayler, Abraham, Owen, Williams, Kehoe, Love: "Distribution and expression of picalm in Alzheimer disease." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 10, pp. 1071-7, (2010) (PubMed).

Aliase für Phosphatidylinositol Binding clathrin Assembly Protein Proteine

leucine aminopeptidase 3 (LAP3) Proteine
phosphatidylinositol binding clathrin assembly protein (PICALM) Proteine
phosphatidylinositol binding clathrin assembly protein (Picalm) Proteine
si:ch211-200p22.4 (si:ch211-200p22.4) Proteine
CALM Proteine
Calm Proteine
CLTH Proteine
fit-1 Proteine
fit1 Proteine
LAP Proteine
LAP-3 Proteine
mKIAA4114 Proteine
PAP180 Proteine
PEPS Proteine
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