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Trichoplein, Keratin Filament Binding (TCHP) (C-Term) Peptid

TCHP Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN984916
  • Target Alle TCHP Produkte
    TCHP (Trichoplein, Keratin Filament Binding (TCHP))
    Protein Region
    C-Term
    Spezies
    Human
    Quelle
    • 1
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-TCHP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    TCHP (Trichoplein, Keratin Filament Binding (TCHP))
    Hintergrund
    TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

    Alias Symbols: MGC10854, TpMs

    Protein Interaction Partner: CCDC85B,KRT14,KRT15,KRT16,KRT18,KRT5,KRT6A,KRT8,NME7,TEX11,VIM,CCDC85B,KRT15,NME7,TEX11,VIM

    Protein Size: 498
    Molekulargewicht
    61 kDa
    Gen-ID
    84260
    NCBI Accession
    NM_032300, NP_115676
    UniProt
    Q9BT92
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