Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Peptid
SIGLEC7
Reaktivität: Human
Wirt: Synthetic
WB, BP
Produktnummer ABIN983743
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Peptid (ABIN983743)
Target
SIGLEC7
(Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
Spezies
Human
Quelle
Synthetic
Applikation
Western Blotting (WB), Blocking Peptide (BP)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-SIGLEC7 antibody (Catalog #: ARP47018_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
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Hintergrund
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SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. In the immune response, it may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC7 mediates inhibition of natural killer cells cytotoxicity. It may also play a role in hemopoiesis. SIGLEC7 inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Alias Symbols: AIRM1, CDw328, D-siglec, QA79, SIGLEC-7, p75, p75/AIRM1, CD328
Protein Interaction Partner: GRB2,PTPN11,TRAF4
Protein Size: 467 -
Molekulargewicht
- 51 kDa
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Gen-ID
- 27036
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NCBI Accession
- NM_014385, NP_055200
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UniProt
- Q9Y286
Target
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