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serine/arginine-Rich Splicing Factor 1 (SRSF1) Peptid

SRSF1 Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN983640
  • Target Alle SRSF1 Produkte
    SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))
    Spezies
    Human
    Quelle
    • 4
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-SFRS1 antibody (Catalog #: ARP40692_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))
    Hintergrund
    SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized (Bermingham et al., 1995).[supplied by OMIM].

    Alias Symbols: ASF, SF2, SFRS1, SF2p33, SRp30a, SRSF1

    Protein Interaction Partner: C1QBP,CD8A,CDK12,CLK1,DIDO1,LNX1,LUC7L3,NFYA,NXF1,PRPF4,PRPF4B,PSIP1,SFRS12,SFRS17A,SIP1,SNRNP70,SRPK1,SRPK2,SRSF11,SRSF2IP,TCERG1,TNPO3,TOP1,U2AF1,U2AF2,YTHDC1,ZRSR2,AIRE,C1QBP,CDC5L,CLK1,DIDO1,DYRK1A,LNX1,LUC7L3,PRPF4,PSIP1,RNPS1,RRP1B,Rrp1b,SF3A2,SKY1,SNRNP70,SRPK1,SRPK2,SRSF1,SRSF11,SRSF2,SRSF2IP,SRSF5,Safb,TCERG1,TOP1,U2AF1,U2AF2,YWHAQ

    Protein Size: 248
    Molekulargewicht
    27 kDa
    Gen-ID
    6426
    NCBI Accession
    NM_006924, NP_008855
    UniProt
    Q07955
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