serine/arginine-Rich Splicing Factor 1 (SRSF1) Peptid
SRSF1
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle SRSF1 Produkte
- SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-SFRS1 antibody (Catalog #: ARP40691_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))
- Synonyme
- ASF Peptide, SF2 Peptide, SF2p33 Peptide, SFRS1 Peptide, SRp30a Peptide, 1110054N12Rik Peptide, 5730507C05Rik Peptide, 6330415C05Rik Peptide, AI482334 Peptide, AW491331 Peptide, Asf Peptide, Sf2 Peptide, Sfrs1 Peptide, DKFZp469K2419 Peptide, sfrs1 Peptide, sfrs1b Peptide, wu:fb80g05 Peptide, zgc:111894 Peptide, zgc:65898 Peptide, zgc:76897 Peptide, asf Peptide, sf2 Peptide, sf2p33 Peptide, srp30a Peptide, sfrs1a Peptide, sfrs1l Peptide, wu:fb52g10 Peptide, wu:fb97g12 Peptide, zgc:66146 Peptide, serine and arginine rich splicing factor 1 Peptide, serine/arginine-rich splicing factor 1 Peptide, serine/arginine-rich splicing factor 1b Peptide, serine/arginine-rich splicing factor 1 L homeolog Peptide, serine/arginine-rich splicing factor 1a Peptide, SRSF1 Peptide, Srsf1 Peptide, srsf1b Peptide, srsf1.L Peptide, srsf1a Peptide
- Hintergrund
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SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized (Bermingham et al., 1995).[supplied by OMIM].
Alias Symbols: ASF, SF2, SFRS1, SF2p33, SRp30a, SRSF1
Protein Interaction Partner: C1QBP,CD8A,CDK12,CLK1,DIDO1,LNX1,LUC7L3,NFYA,NXF1,PRPF4,PRPF4B,PSIP1,SFRS12,SFRS17A,SIP1,SNRNP70,SRPK1,SRPK2,SRSF11,SRSF2IP,TCERG1,TNPO3,TOP1,U2AF1,U2AF2,YTHDC1,ZRSR2,AIRE,C1QBP,CDC5L,CLK1,DIDO1,DYRK1A,LNX1,LUC7L3,PRPF4,PSIP1,RNPS1,RRP1B,Rrp1b,SF3A2,SKY1,SNRNP70,SRPK1,SRPK2,SRSF1,SRSF11,SRSF2,SRSF2IP,SRSF5,Safb,TCERG1,TOP1,U2AF1,U2AF2,YWHAQ
Protein Size: 248 - Molekulargewicht
- 27 kDa
- Gen-ID
- 6426
- NCBI Accession
- NM_006924, NP_008855
- UniProt
- Q07955
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