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Protein Inhibitor of Activated STAT, 2 (PIAS2) (N-Term) Peptid

PIAS2 Reaktivität: Human, Maus Wirt: Synthetic BP, WB
Produktnummer ABIN981731
  • Target Alle PIAS2 Produkte
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Protein Region
    N-Term
    Spezies
    Human, Maus
    Quelle
    • 11
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    PAVQIKIREL YRRRYPRTLE GLCDLSTIKS SVFSLDGSSS PVEPDLPVAG
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-Pias2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Hintergrund
    Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.Pias2 plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing.Pias2 binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha

    Alias Symbols: 6330408K17Rik, AI462206, ARIP3, AU018068, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta, SIZ2

    Protein Interaction Partner: Gtf2i,Hdac3,DHX9,GTF2I,GTF2IRD1,Gtf2i,HDAC3,Nfkb1,Trim32,Trp53

    Protein Size: 580
    Molekulargewicht
    63 kDa
    Gen-ID
    17344
    NCBI Accession
    NM_001164167, NP_001157639
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