Protein Inhibitor of Activated STAT, 2 (PIAS2) Peptid

Details zu Produkt Nr. ABIN981732, Anbieter: Anmelden zum Anzeigen
Proteinname
  • MGC83751
  • piasx
  • wu:fi05f09
  • PIAS2
  • 6330408K17Rik
  • AI462206
  • ARIP3
  • AU018068
  • Dib
  • Miz1
  • PIASxalpha
  • PIASxb
  • PIASxbeta
  • SIZ2
  • DIP
  • MIZ
  • MIZ1
  • PIASX
  • PIASX-ALPHA
  • PIASX-BETA
  • ZMIZ4
  • protein inhibitor of activated STAT 2 L homeolog
  • protein inhibitor of activated STAT 2
  • protein inhibitor of activated STAT, 2
  • pias2.L
  • PIAS2
  • pias2
  • Pias2
Spezies
Human
11
5
3
3
2
2
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Geblockter Antikörper anti-PIAS2 Antikörper (Protein Inhibitor of Activated STAT, 2) (N-Term) (ABIN2785610)
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PIAS2 antibody (Catalog #: ARP53840_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.

Alias Symbols: MGC102682, MIZ1, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz, DIP, MIZ, ARIP3, PIASX

Protein Interaction Partner: GTF2IRD1,HTNVsSgp1,SUMO1,UBE2I,ELK1,AR,BAT1,CHMP4B,ELK1,GRM8,GTF2I,GTF2IRD1,HDAC3,MBD1,MSX2,NAV2,PARK7,PIAS1,SMAD4,SNIP1,STAT4,SUMO1,UBE2I,AKT1,AKT1,AR,CDKN1A,CDKN1A,CDKN1C,CDKN2B,CDV3,DNMT3A,ESR1,ESR2,GTF2IRD1,ITGB5,MYC,NAV2,NR3C1,PARK7,PGR,SIAH1,SIAH2,STAT4,SUMO1,UBE2I,YWHAH

Protein Size: 572
Molekulargewicht 63 kDa
Gen-ID 9063
NCBI Accession NM_173206, NP_775298
Applikationshinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.