Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.
Alias Symbols: MGC102682, MIZ1, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz, DIP, MIZ, ARIP3, PIASX
Protein Interaction Partner: GTF2IRD1,HTNVsSgp1,SUMO1,UBE2I,ELK1,AR,BAT1,CHMP4B,ELK1,GRM8,GTF2I,GTF2IRD1,HDAC3,MBD1,MSX2,NAV2,PARK7,PIAS1,SMAD4,SNIP1,STAT4,SUMO1,UBE2I,AKT1,AKT1,AR,CDKN1A,CDKN1A,CDKN1C,CDKN2B,CDV3,DNMT3A,ESR1,ESR2,GTF2IRD1,ITGB5,MYC,NAV2,NR3C1,PARK7,PGR,SIAH1,SIAH2,STAT4,SUMO1,UBE2I,YWHAH
Protein Size: 572