Paired-Like Homeobox 2a (PHOX2A) (N-Term) Peptid

Details zu Produkt Nr. ABIN981709, Anbieter: Anmelden zum Anzeigen
Proteinname
  • ARIX
  • CFEOM2
  • FEOM2
  • NCAM2
  • PMX2A
  • Arix
  • Phox2
  • Pmx2
  • Pmx2a
  • arix
  • sou
  • zgc:77364
  • phox2
  • xphox2a
  • paired like homeobox 2a
  • paired-like homeobox 2a
  • paired like homeobox 2a S homeolog
  • PHOX2A
  • Phox2a
  • phox2a
  • phox2a.S
Protein Region
N-Term
Spezies
Human
5
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
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Geblockter Antikörper anti-Paired-Like Homeobox 2a (PHOX2A) (N-Term) Antikörper (ABIN2779453)
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PHOX2A antibody (Catalog #: ARP32081_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. PHOX2A has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Alias Symbols: ARIX, CFEOM2, FEOM2, MGC52227, NCAM2, PMX2A

Protein Interaction Partner: ATF6B,CREBBP,HAND2,PHOX2A,PRKACA,CREBBP,HAND2,JUN,PHOX2A

Protein Size: 284
Molekulargewicht 30 kDa
Gen-ID 401
NCBI Accession NM_005169, NP_005160
UniProt O14813
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.