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Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) Peptid

MANF Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN979757
  • Target Alle MANF Produkte
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Protein Region
    C-Term
    Spezies
    Human
    Quelle
    • 4
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    EKICEKLKKK DSQICELKYD KQIDLSTVDL KKLRVKELKK ILDDWGETCK
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-MANF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Hintergrund
    MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

    Alias Symbols: ARMET, ARP, MGC142148, MGC142150

    Protein Size: 185
    Molekulargewicht
    21 kDa
    Gen-ID
    7873
    NCBI Accession
    NM_006010, NP_006001
    UniProt
    A8K878
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