Insulin-Like Growth Factor 1 Receptor (IGF1R) (Middle Region) Peptid
IGF1R
Reaktivität: Human
Wirt: Synthetic
BP, IHC, WB
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- Target Alle IGF1R Produkte
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-IGF1R antibody (Catalog #: AVARP00004_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
- Hintergrund
-
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-140 DR007209.1 566-705 141-3559 X04434.1 136-3554 3560-4540 BC113610.1 3542-4522 4541-4921 DA486252.1 187-567 4922-5392 BX093045.1 248-718 5393-5768 CN414655.1 317-692 5769-6158 BM264223.1 185-574 6159-6580 BQ185364.1 187-608 6581-11242 AC069029.9 21278-25939 c
Alias Symbols: CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216, IGFR
Protein Interaction Partner: CSK,EHD1,GNB2L1,GRB10,IRS1,IRS1,IRS2,ITGB1,JAK1,PIK3R2,PRKCD,PRKD1,SHC1,SOCS1,SOCS2,SOCS3,YWHAB,YWHAE,YWHAZ,ARHGEF12,CRK,CRKL,CSK,DOK4,DOK5,EHD1,ESR1,GIPC1,GNAI1,GNAI2,GNB2L1,GRB10,IGF1,IGF1R,IGF2,IGFBP3,INS,INSR,IRS1,IRS2,IRS4,ITGB1,JAK1,JAK2,KL,KRT27,MAP3K5,MDM2,NEDD4,PIK3R1,PIK3R2,PIK3R3,PRKCD,PRKD1,PTPN1,PTPN11,RASA1,SOCS1,SOCS2,SOCS3,SRC,STAT3,VAV3,WISP2,YWHAB,YWHAE,YWHAG,YWHAZ,ARHGEF12,CBL,CSK,EEA1,EGFR,EHD1,ESR1,GNAI1,GNB2L1,GRB10,IGF1,IGFBP3,IRS1,JAK1,MDM2,NEDD4,PIK3R3,PTK2,PTPN1,PTPN11,PXN,RASA1,SHC1,SNAP29,SOCS1,SOCS2,SOCS3,UBC,VAV3,YWHAB,YWHAE,YWHAG
Protein Size: 1367 - Molekulargewicht
- 71 kDa
- Gen-ID
- 3480
- NCBI Accession
- NM_000875, NP_000866
- UniProt
- P08069
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